Ethyl 2-aminopropanoate hydrochloride

Base Information

• Chemical Name: Ethyl 2-aminopropanoate hydrochloride
• CAS No.: 617-27-6
• Molecular Formula: C5H11NO2^.HCl
• Molecular Weight: 153.609
• Hs Code.: 29224999
• European Community (EC) Number: 210-507-0,214-225-9
• NSC Number: 156973,46032,45688
• DSSTox Substance ID: DTXSID40883470
• Mol file: 617-27-6.mol

Synonyms:617-27-6;ethyl 2-aminopropanoate hydrochloride;DL-Alanine ethyl ester hydrochloride;H-DL-Ala-OEt.HCl;dl-alanine ethyl ester hcl;D,L-Alanine Ethyl Ester Hydrochloride;MFCD00013018;h-dl-ala-oet hydrochloride;ethyl 2-aminopropanoate;hydrochloride;Alanine, ethyl ester, hydrochloride;Alanine, ethyl ester, hydrochloride (1:1);NSC 46032;Ethyl alaninate hydrochloride;Ethyl alaninate HCl;H-D-Ala-Oet.HCl;EINECS 210-507-0;DL-Ethyl 2-aminopropanoate hydrochloride;EINECS 214-225-9;MFCD00190725;L-Ethyl 2-aminopropanoate hydrochloride;H-b-Ala-OEt.HCl;alanine ethyl ester hcl;3,3-DIMETHOXYBENZOIN;SCHEMBL135306;DL-AlaninEthyl esterhydrochloride;DTXSID40883470;DL-alanine ethylester hydrochloride;NSC45688;NSC46032;Ethyl alaninate hydrochloride (1:1);ethyl-2-aminopropanoate hydrochloride;NSC-45688;NSC-46032;NSC156973;AKOS009156436;DL-Alanine, ethyl ester, hydrochloride;FD21071;HY-W099247;NSC-156973;Alanine, ethyl ester, hydrochloride, DL-;AS-12779;SY004290;SY021480;AM20100508;CS-0151889;FT-0601298;FT-0625416;FT-0689469;EN300-53367;2-aminopropionic acid ethyl ester hydrochloride;A833397;[(2S)-1-Ethoxy-1-oxopropan-2-yl]azanium;chloride;DL-Alanine ethyl ester hydrochloride, >=99.0% (AT);1,2,3,6,7,11|A-Hexahydro-4H-pyrazino[2,1-a]isoquinoline-4-one

Chemical Property of Ethyl 2-aminopropanoate hydrochloride

Chemical Property:

• Appearance/Colour: white crystalline solid
• Vapor Pressure: 11mmHg at 25°C
• Melting Point: 85-87 °C(lit.)
• Boiling Point: 127.8 °C at 760 mmHg
• Flash Point: 3.5 °C
• PSA: 52.32000
• Density: 0.821 g/cm3
• LogP: 1.39900
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Sparingly), Water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 153.0556563
• Heavy Atom Count: 9
• Complexity: 82.5

Purity/Quality:

99% ^*data from raw suppliers

DL-Alanine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)C(C)N.Cl
• Uses: Alanine derivative

Technology Process of Ethyl 2-aminopropanoate hydrochloride

There total 10 articles about Ethyl 2-aminopropanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethanol (64-17-5) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) → DL-alanine ethyl ester hydrochloride (617-27-6)

Guidance literature:

With thionyl chloride; for 2h; Heating;

Reference yield: 91.0%

rac-Ala-OH (302-72-7,25191-17-7,18875-37-1) → DL-alanine ethyl ester hydrochloride (617-27-6)

Guidance literature:

In ethanol;

Reference yield: 62.0%

C14H28NO7P (85231-99-8) → DL-alanine ethyl ester hydrochloride (617-27-6)

Guidance literature:

With hydrogenchloride; In benzene; Ambient temperature;

DOI:10.1055/s-1982-29997

upstream raw materials:

hexamethylenetetramine

2-Bromopropionic acid

C₁₄H₂₈NO₇P

ethanol

Downstream raw materials:

2-Isocyanatopropionsaeure-ethylester

2-isothiocyanatopropionic acid ethyl ester

2-[(R)-2-(Trityl-amino)-3-tritylsulfanyl-propionylamino]-propionic acid ethyl ester

DL-alanine hydroxamic acid

Refernces

• 1、 Korch, Katerina M.,Eidamshaus, Christian,Behenna, Douglas C.,Stoltz, Brian M.,Nam, Sangkil,Horne, David. "Enantioselective synthesis of α-secondary and α-tertiary piperazin-2- Ones and piperazines by catalytic asymmetric allylic alkylation". supporting information. p. 179 - 183. Retrieved 2015/02/05.
• 2、 Xue, Sijia,Bu, Hongfei,Liu, Li,Xu, Xiao,Ma, Xubo. "Synthesis, crystal structure and insecticidal activity of the optical active neonicotinoid analogues". scheme or table. p. 1011 - 1016. Retrieved 2012/01/06.