Benzenebutanoic acid, b-phenyl-, methyl ester

Base Information

Chemical Name:Benzenebutanoic acid, b-phenyl-, methyl ester
CAS No.:141885-87-2
Molecular Formula:C17H18O2
Molecular Weight:254.329
Hs Code.:

Synonyms:

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Chemical Property of Benzenebutanoic acid, b-phenyl-, methyl ester

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Technology Process of Benzenebutanoic acid, b-phenyl-, methyl ester

There total 6 articles about Benzenebutanoic acid, b-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 103-26-4,1754-62-7
Methyl cinnamate

: 6921-34-2
benzylmagnesium chloride

: 141885-87-2
methyl-3,4-diphenylbutanoate

Guidance literature:: With copper(l) iodide; chloro-trimethyl-silane; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; -78 deg C up to -40 deg C over 24 h;
DOI:10.1016/S0040-4039(00)74218-3

Reference yield:

: 103-26-4,1754-62-7
methyl cinnamate

: 6921-34-2
benzylmagnesium chloride

: 141885-87-2
methyl-3,4-diphenylbutanoate

Guidance literature:: benzylmagnesium chloride; With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

methyl cinnamate; With chloro-trimethyl-silane; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 4h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.1c00781

Reference yield:

: 100-44-7
benzyl chloride

: 141885-87-2
methyl-3,4-diphenylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / 2.5 h / 0 - 20 °C / Inert atmosphere

1.2: 24 h / -78 - -30 °C / Inert atmosphere

2.1: ammonium hydroxide; ammonium chloride / 25 °C / Saturated solution

With ammonium hydroxide; ammonium chloride; magnesium; In tetrahydrofuran; 1.1: Michael condensation;
DOI:10.1002/asia.201000804