1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil

Base Information

Chemical Name:1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil
CAS No.:137897-87-1
Molecular Formula:C16H20N2O3S2
Molecular Weight:352.4716
Hs Code.:
DSSTox Substance ID:DTXSID40160379
Nikkaji Number:J457.572E
ChEMBL ID:CHEMBL417448
Mol file:137897-87-1.mol

Synonyms:5-PrHEPT-S;137897-87-1;1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil;1-[(2-Hydroxyethoxy)methyl]-6-(phenylthio)-5-propyl-2-thiouracil;CHEMBL417448;DTXSID40160379;1,2-Dihydro-5-propyl-1-(2-hydroxyethoxymethyl)-6-(phenylthio)-2-thioxopyrimidin-4(3H)-one;1-(2-hydroxyethoxymethyl)-6-phenylsulfanyl-5-propyl-2-thioxo-pyrimidin-4-one

Suppliers and Price of 1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.34g/cm³
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:352.09153485
Heavy Atom Count:23
Complexity:462

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1=C(N(C(=S)NC1=O)COCCO)SC2=CC=CC=C2

Technology Process of 1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil

There total 3 articles about 1-((2-Hydroxyethoxy)methyl)-6-(phenylthio)-5-propyl-2-thiouracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-phenylsulfanyl-5-propyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

: 137897-87-1
5-propyl-1-<(2-hydroxyethoxy)methyl>-6-(phenylthio)-2-thiouracil

Guidance literature:: With hydrogenchloride; for 2h; Yield given; Ambient temperature;
DOI:10.1021/jm00080a020

Reference yield:

: 137897-84-8
1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-5-propyl-2-thiouracil

: 137897-87-1
5-propyl-1-<(2-hydroxyethoxy)methyl>-6-(phenylthio)-2-thiouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: HCl (conc.) / 2 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;
DOI:10.1021/jm00080a020

Reference yield:

: 882-33-7
diphenyldisulfane

: 137897-87-1
5-propyl-1-<(2-hydroxyethoxy)methyl>-6-(phenylthio)-2-thiouracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -70 deg C, 1 h, 2.) THF, -70 deg C, 1 h

2: HCl (conc.) / 2 h / Ambient temperature

With hydrogenchloride; lithium diisopropyl amide;
DOI:10.1021/jm00080a020