N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide

Base Information

• Chemical Name: N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide
• CAS No.: 142071-84-9
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288
• DSSTox Substance ID: DTXSID70568541
• Wikidata: Q82454826
• Mol file: 142071-84-9.mol

Synonyms:142071-84-9;N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide;N-benzyl-N'-o-hydroxyphenyloxamide;SCHEMBL20414994;DTXSID70568541

Chemical Property of N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 270.10044231
• Heavy Atom Count: 20
• Complexity: 340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CNC(=O)C(=O)NC2=CC=CC=C2O

Technology Process of N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide

There total 6 articles about N~1~-Benzyl-N~2~-(2-hydroxyphenyl)ethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[(2-hydroxyphenyl)amino]-2-oxo-acetate (91004-40-9) + benzylamine (100-46-9) → N-benzyl-N'-o-hydroxyphenyloxamide (142071-84-9)

Guidance literature:

In tetrahydrofuran; at 70 ℃; for 18h;

DOI:10.1021/acs.orglett.7b01403

Reference yield:

3-benzoylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione (142071-82-7) → N-benzyl-N'-o-hydroxyphenyloxamide (142071-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / dioxane / 0.17 h / Ambient temperature

2: acetonitrile

In 1,4-dioxane; acetonitrile;

Reference yield:

N-(2-Hydroxy-phenyl)-2,4-dioxo-3-[3-oxo-3,4-dihydro-1H-quinoxalin-(2Z)-ylidene]-4-phenyl-butyramide (175472-78-3) → N-benzyl-N'-o-hydroxyphenyloxamide (142071-84-9) + (Z)-3-phenacylidene-1,2,3,4-tetrahydroquinoxalin-2-one (32781-10-5,39260-15-6)

Guidance literature:

With benzylamine; In acetonitrile; Yield given. Yields of byproduct given;

upstream raw materials:

benzylamine

N-(2-Hydroxy-phenyl)-2,4-dioxo-3-[3-oxo-3,4-dihydro-1H-quinoxalin-(2Z)-ylidene]-4-phenyl-butyramide

3-benzoylpyrrolo[2,1-c][1,4]benzoxazine-1,2,4-trione

1,2-diamino-benzene