1-Propanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

• Chemical Name: 1-Propanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
• CAS No.: 142072-07-9
• Molecular Formula: C9H22O2Si
• Molecular Weight: 190.35500
• Mol file: 142072-07-9.mol

Synonyms:2-(tert-Butyl-dimethyl-silanyloxy)-propan-1-ol;2-(tert-butyldimethylsilanyloxy)propanol;2-(tert-butyldimethylsilanyloxy)-propan-1-ol;

Chemical Property of 1-Propanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

• PSA: 29.46000
• LogP: 2.38900

Purity/Quality:

99% ^*data from raw suppliers

2-(tert-Butyldimethylsilanyloxy)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-(tert-Butyldimethylsilanyloxy)propan-1-ol is an intermediate in the synthesis of Cetirizine (C291155), an nonsedating type histamine H1-receptor antagonist.

Technology Process of 1-Propanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 7 articles about 1-Propanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2-benzyloxy-1-methyl-ethoxy)-tert-butyl-dimethyl-silane (1009334-99-9) → 2-tert-butyldimethylsiloxy-1-propanol (142072-07-9)

Guidance literature:

With hydrogen; palladium on carbon; In ethyl acetate; for 3h;

Reference yield: 84.0%

2-(tert-Butyl-dimethyl-silanyloxy)-1-triethylsilanyloxy-propane (142072-00-2) → 2-tert-butyldimethylsiloxy-1-propanol (142072-07-9)

Guidance literature:

With methyl magnesium iodide; In diethyl ether; for 1.25h; Ambient temperature;

DOI:10.1039/c39920000681

Reference yield: 54.0%

1,2-bis(tert-butyldimethylsiloxy)propane → 2-tert-butyldimethylsiloxy-1-propanol (142072-07-9)

Guidance literature:

With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.biochem.8b00031

upstream raw materials:

2-(tert-Butyl-dimethyl-silanyloxy)-1-triethylsilanyloxy-propane

propylene glycol

tert-butyldimethylsilane

(S)-(-)-ethyl 2-(tert-butyldimethylsilyloxy)propanoate