Imidazo[1,2-a]pyridine, 2-phenyl-6-(phenylthio)-

Base Information

• Chemical Name: Imidazo[1,2-a]pyridine, 2-phenyl-6-(phenylthio)-
• CAS No.: 142074-05-3
• Molecular Formula: C19H14N2S
• Molecular Weight: 302.4
• Mol file: 142074-05-3.mol

Synonyms:

Chemical Property of Imidazo[1,2-a]pyridine, 2-phenyl-6-(phenylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Imidazo[1,2-a]pyridine, 2-phenyl-6-(phenylthio)-

There total 4 articles about Imidazo[1,2-a]pyridine, 2-phenyl-6-(phenylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

thiophenol (108-98-5) + 2-phenyl-6-iodoimidazo[1,2-a]pyridine (61982-63-6) → 2-phenyl-6-phenylthioimidazo<1,2-a>pyridine (142074-05-3)

Guidance literature:

With iron(II) chloride tetrahydrate; caesium carbonate; copper(II) oxide; In N,N-dimethyl-formamide; at 135 ℃; for 24h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1055/s-0034-1380383

Reference yield:

α-bromoacetophenone (70-11-1) → 2-phenyl-6-phenylthioimidazo<1,2-a>pyridine (142074-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 12 h / Inert atmosphere; Reflux

2: copper(II) oxide; caesium carbonate; iron(II) chloride tetrahydrate / N,N-dimethyl-formamide / 24 h / 135 °C / Sealed tube; Inert atmosphere

With iron(II) chloride tetrahydrate; sodium hydrogencarbonate; caesium carbonate; copper(II) oxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1055/s-0034-1380383

Reference yield:

2-amino-5-iodopyridine (20511-12-0) → 2-phenyl-6-phenylthioimidazo<1,2-a>pyridine (142074-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethanol / 12 h / Inert atmosphere; Reflux

2: copper(II) oxide; caesium carbonate; iron(II) chloride tetrahydrate / N,N-dimethyl-formamide / 24 h / 135 °C / Sealed tube; Inert atmosphere

With iron(II) chloride tetrahydrate; sodium hydrogencarbonate; caesium carbonate; copper(II) oxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1055/s-0034-1380383

upstream raw materials:

2-Amino-5-(phenylthio)pyridin

α-bromoacetophenone

thiophenol

2-phenyl-6-iodoimidazo[1,2-a]pyridine

Downstream raw materials:

3-acetamodomethyl-2-phenyl-6-phenylthioimidazo<1,2-a>pyridine

6-benzamidomethyl-2-phenyl-6-phenylthioimidazol<1,2-a>pyridine