3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester
CAS No.:142161-40-8
Molecular Formula:C₂₉H₂₅ClN₄O₄
Molecular Weight:528.995
Hs Code.:

3,5-Pyridinedicarboxylic acid,
4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5-
c]pyridin-1-yl)phenyl]-, 5-ethyl ester

Synonyms:

Suppliers and Price of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester

There total 12 articles about 3,5-Pyridinedicarboxylic acid, 4-(2-chlorophenyl)-1,4-dihydro-2-methyl-6-[4-(2-methyl-1H-imidazo[4,5- c]pyridin-1-yl)phenyl]-, 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 142161-47-5,122957-02-2,122957-03-3
4-(2-chlorophenyl)-5-<(2-cyanoethoxy)carbonyl>-1,4-dihydro-3-(ethoxycarbonyl)-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>pyridine

: 142161-40-8,122957-04-4,122957-05-5
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>-pyridine-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1h;
DOI:10.1021/jm00095a005

Reference yield:

: 13091-23-1
4-chloro-3-nitropyridine

: 142161-40-8,122957-04-4,122957-05-5
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>-pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / ethanol / 18 h / 20 °C

2: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

3: 81 percent / acetic acid / 2 h / 90 °C

4: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

5: 44 percent / ethanol / 8 h / Heating

6: 96 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

With sodium hydroxide; hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jm00095a005

Reference yield:

: 122957-33-9
4-[N-(4-cyanophenyl)amino]-3-nitropyridine

: 142161-40-8,122957-04-4,122957-05-5
4-(2-chlorophenyl)-1,4-dihydro-3-(ethoxycarbonyl)-6-methyl-2-<4-(2-methylimidazo<4,5-c>pyrid-1-yl)phenyl>-pyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 2 h / 20 °C / 1551.4 Torr

2: 81 percent / acetic acid / 2 h / 90 °C

3: 1.) Zn, 2.) 20percent aq. TFA / 1.) THF, reflux, 10 min, 2.) CH₂Cl₂, RT, 15 min

4: 44 percent / ethanol / 8 h / Heating

5: 96 percent / NaOH / dioxane; H₂O / 1 h / 20 °C

With sodium hydroxide; hydrogen; trifluoroacetic acid; zinc; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jm00095a005