1H-Indole-1-carboxylic acid, 5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl ]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)-

Base Information

Chemical Name:1H-Indole-1-carboxylic acid, 5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl ]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)-
CAS No.:142165-90-0
Molecular Formula:C₃₂H₃₃N₃O₈
Molecular Weight:587.629
Hs Code.:

1H-Indole-1-carboxylic acid,
5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl
]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)-

Synonyms:

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Chemical Property of 1H-Indole-1-carboxylic acid, 5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl ]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)-

Chemical Property:

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Technology Process of 1H-Indole-1-carboxylic acid, 5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl ]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)-

There total 5 articles about 1H-Indole-1-carboxylic acid, 5-[[[4-[[3-(ethoxycarbonyl)phenyl]amino]-1-(methoxycarbonyl)-4-oxobutyl ]amino]carbonyl]-2,3-dihydro-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 582-33-2
3-aminobenzoic acid ethyl ester

: 142165-90-0
methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) / CH₂Cl₂ / Ambient temperature

2: 88 percent / TFA / 0.5 h / Ambient temperature

3: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1248/cpb.45.1146

Reference yield:

: 72086-72-7
N-tert-butoxycarbonylglutamic acid methyl ester

: 142165-90-0
methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) / CH₂Cl₂ / Ambient temperature

2: 88 percent / TFA / 0.5 h / Ambient temperature

3: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1248/cpb.45.1146

Reference yield:

: 142165-63-7
1-carbobenzoxy-5-carboxyindoline

: 142165-90-0
methyl N^α-[(1-benzyloxycarbonylindolin-5-yl)carbonyl]-N^δ-(3-ethoxycarbonylphenyl)-L-glutaminate

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / 1 h

2: aq. K₂CO₃ / CH₂Cl₂ / 10 h / Ambient temperature

With thionyl chloride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1146