Phenol, 4-(2-methoxyethoxy)-3-(phenylmethoxy)-

Base Information

Chemical Name:Phenol, 4-(2-methoxyethoxy)-3-(phenylmethoxy)-
CAS No.:142206-55-1
Molecular Formula:C16H18O4
Molecular Weight:274.317
Hs Code.:

Synonyms:

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Chemical Property of Phenol, 4-(2-methoxyethoxy)-3-(phenylmethoxy)-

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Technology Process of Phenol, 4-(2-methoxyethoxy)-3-(phenylmethoxy)-

There total 1 articles about Phenol, 4-(2-methoxyethoxy)-3-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(benzyloxy)-4-(2-methoxyethoxy)benzaldehyde

: 142206-55-1
3-benzyloxy-4-(2-methoxyethoxy)phenol

Guidance literature:: With potassium fluoride; sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1) CH₂Cl₂, r.t., 4 h, 2) CH₂Cl₂, H₂O, r.t., 30 min;

Reference yield: 99.0%

: 142206-55-1
3-benzyloxy-4-(2-methoxyethoxy)phenol

: 74-88-4
methyl iodide

: 2-benzyloxy-4-methoxy-1-(2-methoxyethoxy)benzene

Guidance literature:: With sodium hydride; In tetrahydrofuran; paraffin; for 48h; Ambient temperature;

Reference yield:

: 142206-55-1
3-benzyloxy-4-(2-methoxyethoxy)phenol

: 142216-56-6
1α-(tert-butyldimethylsilyl)oxy-2α-(2,6-dimethoxyphenoxy)-6α-<4-hydroxy-2-methoxy-5-(2-methoxyethoxy)phenyl>-3,7-dioxabicyclo<3.3.0>octane

Guidance literature:: Multi-step reaction with 17 steps

1: 99 percent / NaH / tetrahydrofuran; paraffin / 48 h / Ambient temperature

2: 83 percent / POCl₃ / 1 h / 60 °C

3: 47 percent / i-Pr₂NLi / tetrahydrofuran / 2 h / -75 °C

4: 86 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

5: 67 percent / LiAlH₄ / diethyl ether / 0.5 h / -10 °C

6: 1) 2percent aq. OsO₄, N-methylmorpholine N-oxide, 2) NaIO₄ / 1) acetone, t-BuOH, r.t., 16 h, 2) EtOAc, H₂O, r.t., 2 h

7: 93 percent / Ag₂CO₃, celite / benzene / 0.5 h / Heating

8: 1) Et₃N, MeSO₂Cl, 2) Et₃N / 1) benzene, r.t., 2 h, 2) benzene, r.t., 16 h

9: 98 percent / N-methylmorpholine N-oxide, 2percent aq. OsO₄ / acetone; 2-methyl-propan-2-ol / 24 h / Ambient temperature

10: 94 percent / Bu₄NF / tetrahydrofuran / 1 h / 0 °C

11: 57 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 16 h / Ambient temperature

12: 82 percent / H₂ / Pd/C / ethyl acetate / 4 h / 760 Torr / Ambient temperature

13: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / Ambient temperature

14: 69 percent / DIBAL-H / toluene / 0.5 h / -75 °C

15: 74 percent / 2-fluoro-1-methylpyridinium tosylate, Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

16: 66 percent / trimethylsilyl trifluoromethanesulfonate / diethyl ether / 7 h / 0 °C

17: 40 percent / Bu₄NF / tetrahydrofuran; acetonitrile / 3 h / Ambient temperature

With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trimethylsilyl trifluoromethanesulfonate; Celite; (1S)-10-camphorsulfonic acid; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; 1-methyl-2-fluoropyridinium p-toluenesulfonate; methanesulfonyl chloride; 4-methylmorpholine N-oxide; triethylamine; silver carbonate; lithium diisopropyl amide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; paraffin; tert-butyl alcohol; benzene;