Technology Process of Pyrrolo[3,4-b]pyrrol-6(1H)-one,
hexahydro-1-[(4-methoxyphenyl)methyl]-5-(phenylmethoxy)-, cis-
There total 7 articles about Pyrrolo[3,4-b]pyrrol-6(1H)-one,
hexahydro-1-[(4-methoxyphenyl)methyl]-5-(phenylmethoxy)-, cis- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ortho-nitrophenyl selenocyanate; tributylphosphine;
In
tetrahydrofuran;
for 1h;
Ambient temperature;
DOI:10.1016/S0040-4020(01)88493-3
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pyridine-borane complex, 10percent aqueous hydrochloric acid / ethanol / Ambient temperature
2: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.
3: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH2Cl2, -78 deg C
4: methanol
5: 90 percent / hydrogen, acetic acid / platinum(IV) oxide / ethyl acetate / 760 Torr
6: 69 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
7: 60 percent / o-nitrophenylselenocyanate, tributylphosphine / tetrahydrofuran / 1 h / Ambient temperature
With
hydrogenchloride; ortho-nitrophenyl selenocyanate; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; borane pyridine complex; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
DOI:10.1016/S0040-4020(01)88493-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.
2: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH2Cl2, -78 deg C
3: methanol
4: 90 percent / hydrogen, acetic acid / platinum(IV) oxide / ethyl acetate / 760 Torr
5: 69 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h
6: 60 percent / o-nitrophenylselenocyanate, tributylphosphine / tetrahydrofuran / 1 h / Ambient temperature
With
ortho-nitrophenyl selenocyanate; tributylphosphine; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1016/S0040-4020(01)88493-3
