1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

Base Information

Chemical Name:1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole
CAS No.:142229-36-5
Molecular Formula:C₃₇H₄₂N₂O₄Si
Molecular Weight:606.837
Hs Code.:

Synonyms:1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

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Chemical Property of 1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

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Technology Process of 1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

There total 8 articles about 1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 127793-62-8
4-((tert-butyldiphenylsilyl)oxy)butanal

: 142229-36-5
1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / hydroxylamine hydrochloride, triethylamine / methanol / 17 h

2: 1) n-butyllithium / 1) THF, hexane, -78 deg C -> 0 deg C, 2) THF, -78 deg C

3: pyridine-borane complex, 10percent aqueous hydrochloric acid / ethanol / Ambient temperature

4: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.

5: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

6: methanol

With hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; sodium methylate; borane pyridine complex; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In methanol; ethanol;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: 132047-92-8
tert-butyl(pent-4-en-1-yloxy)diphenylsilane

: 142229-36-5
1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 7 steps

1: 82 g / 1a) ozone, 1b) dimethylsulphide / CH₂Cl₂; methanol / 1a) -78 deg C, 6 h, 1b) r.t., 3 h

2: 81 percent / hydroxylamine hydrochloride, triethylamine / methanol / 17 h

3: 1) n-butyllithium / 1) THF, hexane, -78 deg C -> 0 deg C, 2) THF, -78 deg C

4: pyridine-borane complex, 10percent aqueous hydrochloric acid / ethanol / Ambient temperature

5: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.

6: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

7: methanol

With hydrogenchloride; n-butyllithium; dimethylsulfide; hydroxylamine hydrochloride; sodium methylate; borane pyridine complex; ozone; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In methanol; ethanol; dichloromethane;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: 142229-17-2,142229-31-0
4-tert.-butyldiphenylsilyloxybutanal oxime

: 142229-36-5
1-benzyloxy-4-(2-tert.-butyldiphenylsilyloxyethyl)-3-(4-methoxybenzylamino)-2-oxo-2,5-dihydropyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-butyllithium / 1) THF, hexane, -78 deg C -> 0 deg C, 2) THF, -78 deg C

2: pyridine-borane complex, 10percent aqueous hydrochloric acid / ethanol / Ambient temperature

3: 1) sodium methoxide / 1) MeOH, reflux, 2) r.t.

4: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C

5: methanol

With hydrogenchloride; n-butyllithium; sodium methylate; borane pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; In methanol; ethanol;
DOI:10.1016/S0040-4020(01)88493-3