3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 142253-46-1
• Molecular Formula: C11H18N2O2
• Molecular Weight: 210.27300
• Hs Code.: 2933990090
• Mol file: 142253-46-1.mol

Synonyms:3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;

Chemical Property of 3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0.000203mmHg at 25°C
• Boiling Point: 327.4oC at 760 mmHg
• Flash Point: 151.8oC
• PSA: 53.33000
• Density: 1.062g/cm3
• LogP: 2.09498
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-butyl3-(cyanomethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 13 articles about 3-CYANOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

tert-butyl (Z)-3-(cyanomethylene)pyrrolidine-1-carboxylate → tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate (142253-46-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2021.113724

Reference yield: 94.8%

sodium cyanide (773837-37-9) + tert-butyl (S)-3-(4-methylbenzenesulfonyloxymethyl)pyrrolidine-1-carboxylate (1391730-27-0,114214-70-9) → (R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate (274692-07-8,142253-46-1)

Guidance literature:

In dimethyl sulfoxide; at 90 ℃;

Reference yield: 94.0%

tert-butyl-3-(cyanomethylene)pyrrolidine-1-carboxylate (1339892-43-1) → tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate (142253-46-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h;

upstream raw materials:

2-hydroxy-2-methylpropanenitrile

tert-butyl (S)-3-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate

tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

sodium cyanide

Downstream raw materials:

(R)-tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

(R)-3-carboxymethyl-pyrrolidin-1-carboxylic acid tert-butyl ester

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