Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate
CAS No.:890849-28-2
Molecular Formula:C₁₁H₁₉NO₃
Molecular Weight:213.277
Hs Code.:
European Community (EC) Number:875-331-4
DSSTox Substance ID:DTXSID10697021
Mol file:890849-28-2.mol

Synonyms:890849-28-2;TERT-BUTYL 3-(2-OXOETHYL)PYRROLIDINE-1-CARBOXYLATE;tert-butyl 3-(formylmethyl)pyrrolidine-1-carboxylate;1-Boc-3-(formylmethyl)pyrrolidine;(S)-tert-Butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate;3-(2-oxoethyl)-1-pyrrolidinecarboxylic acid tert-butyl ester;SCHEMBL1899642;DTXSID10697021;XPZCYZRSVIZGRM-UHFFFAOYSA-N;MFCD11977329;SB50294;EN300-112652;A843066;F1913-6929;Z1445951318;TERT-BUTYL3-(2-OXOETHYL)PYRROLIDINE-1-CARBOXYLATE;tert-butyl 3-(2-oxidanylideneethyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylicacid,3-(2-oxoethyl)-,1,1-dimethylethyl ester

Suppliers and Price of Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl 3-(formylmethyl)pyrrolidine-1-carboxylate
5g
$ 4050.00

Matrix Scientific
tert-Butyl 3-(formylmethyl)pyrrolidine-1-carboxylate
1g
$ 1350.00

Matrix Scientific
tert-Butyl 3-(formylmethyl)pyrrolidine-1-carboxylate
500mg
$ 900.00

Acrotein
1-Boc-3-(formylmethyl)pyrrolidine 97%
0.5g
$ 403.34

Total 6 raw suppliers

Chemical Property of Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Chemical Property:

PSA：46.61000
LogP:1.77030
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:213.13649347
Heavy Atom Count:15
Complexity:245

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 3-(formylmethyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(C1)CC=O

Technology Process of Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

There total 4 articles about Tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.4%

: 274692-07-8,142253-46-1
(R)-tert-butyl 3-(cyanomethyl)pyrrolidine-1-carboxylate

: 890849-28-2
(R)-tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; at -65 ℃; for 2h; Inert atmosphere;

Reference yield:

: 199174-24-8
tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate

: 890849-28-2
(R)-tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: dimethyl sulfoxide / 90 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -65 °C / Inert atmosphere

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 138108-72-2
tert-butyl (R)-3-hydroxymethylpyrrolidine-1-carboxylate

: 890849-28-2
(R)-tert-butyl 3-(2-oxoethyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: dimethyl sulfoxide / 90 °C

3: diisobutylaluminium hydride / tetrahydrofuran / 2 h / -65 °C / Inert atmosphere

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;