2,4-Dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine

Base Information

• Chemical Name: 2,4-Dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine
• CAS No.: 142271-98-5
• Molecular Formula: C18H15N3
• Molecular Weight: 273.337
• DSSTox Substance ID: DTXSID70415869
• Nikkaji Number: J481.667F
• Wikidata: Q82224914
• Mol file: 142271-98-5.mol

Synonyms:2,4-dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine;142271-98-5;Imidazo[1,2-a][1,8]naphthyridine, 2,4-dimethyl-8-phenyl-;DTXSID70415869;2,4-DIMETHYL-8-PHENYLIMIDAZO[1,2-A]1,8-NAPHTHYRIDINE;InChI=1/C18H15N3/c1-12-10-13(2)19-18-15(12)8-9-17-20-16(11-21(17)18)14-6-4-3-5-7-14/h3-11H,1-2H

Chemical Property of 2,4-Dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine

Chemical Property:

• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 273.126597491
• Heavy Atom Count: 21
• Complexity: 366

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC2=C1C=CC3=NC(=CN32)C4=CC=CC=C4)C

Technology Process of 2,4-Dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine

There total 1 articles about 2,4-Dimethyl-8-phenylimidazo[1,2-a][1,8]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

7-amino-2,4-dimethyl-1,8-naphthyridine (39565-07-6) + α-bromoacetophenone (70-11-1) → 2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine (142271-98-5)

Guidance literature:

In ethanol; for 3h; Heating;

Reference yield: 98.0%

2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine (142271-98-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,4-Dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine-9-carbaldehyde (180198-60-1)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1h;

Reference yield: 61.0%

2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine (142271-98-5) + acetic acid (64-19-7,77671-22-8) → 1-chloro-6,8-dimethyl-2-phenylimidazo<1,2-a><1,8>naphthyridine (142272-04-6) + 5-acetoxy-1,4-dichloro-6,8-dimethyl-2-phenyl-4,5-dihydroimidazo<1,2-a><1,8>naphthyridine (142272-05-7)

Guidance literature:

With potassium acetate; acetic anhydride; nitrosylchloride; for 0.166667h; Ambient temperature;

upstream raw materials:

7-amino-2,4-dimethyl-1,8-naphthyridine

α-bromoacetophenone

Downstream raw materials:

1-chloro-6,8-dimethyl-2-phenylimidazo<1,2-a><1,8>naphthyridine

5-acetoxy-1,4-dichloro-6,8-dimethyl-2-phenyl-4,5-dihydroimidazo<1,2-a><1,8>naphthyridine

2,4-Dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridine-9-carbaldehyde

(Z)-2-Azido-3-(2,4-dimethyl-8-phenyl-imidazo[1,2-a][1,8]naphthyridin-9-yl)-acrylic acid ethyl ester