4-tert-butylphthalic acid

Base Information

• Chemical Name: 4-tert-butylphthalic acid
• CAS No.: 14236-13-6
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Hs Code.: 2917399090
• Mol file: 14236-13-6.mol

Synonyms:4-tert-Butyl-phthalsaeure;

Chemical Property of 4-tert-butylphthalic acid

Chemical Property:

• Melting Point: 160-161 °C
• Boiling Point: 375.7±42.0 °C(Predicted)
• PKA: 3.35±0.10(Predicted)
• PSA: 74.60000
• Density: 1.226±0.06 g/cm3(Predicted)
• LogP: 2.38050
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(tert-Butyl)phthalicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-tert-butylphthalic acid

There total 11 articles about 4-tert-butylphthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

4-t-butyl-o-xylene (7397-06-0) → 4-(tert-butyl)phthalic acid (14236-13-6)

Guidance literature:

With potassium permanganate; acetic acid; In water; tert-butyl alcohol; Reflux;

Reference yield: 55.0%

4-tert-butylphthalic anhydride (32703-79-0) → 4-(tert-butyl)phthalic acid (14236-13-6)

Guidance literature:

4-tert-butylphthalic anhydride; With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water;

DOI:10.1016/j.bmcl.2009.07.018

Reference yield:

2,6-di-tert-butyl-1,4-naphthoquinone (31592-22-0) → 4-(tert-butyl)phthalic acid (14236-13-6)

Guidance literature:

With potassium permanganate;

DOI:10.1021/ja01633a052

upstream raw materials:

4-t-butyl-o-xylene

2,6-di-tert-butyl-1,4-naphthoquinone

water

o-xylene

Downstream raw materials:

4-(t-butyl)phthalonitrile

4-tert-butyl-phthalic acid diethyl ester

4-tert-butylphthalimide

4-tert-butylphthalic anhydride

Refernces

• 1、 -. "Preparation method of 4 -tert-butyl phthalonitrile (by machine translation)". Paragraph 0023; 0025; 0029; 0031; 0035; 0037. . Retrieved 2020/09/20.
• 2、 Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki. "Metallo-β-lactamase inhibitory activity of phthalic acid derivatives". scheme or table. p. 5162 - 5165. Retrieved 2010/03/24.