2-Thiopheneheptanoic acid, 5-methyl-3-(3-phenylpropyl)-

Base Information

• Chemical Name: 2-Thiopheneheptanoic acid, 5-methyl-3-(3-phenylpropyl)-
• CAS No.: 142422-74-0
• Molecular Formula: C21H28O2S
• Molecular Weight: 344.518
• Mol file: 142422-74-0.mol

Synonyms:

Chemical Property of 2-Thiopheneheptanoic acid, 5-methyl-3-(3-phenylpropyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Thiopheneheptanoic acid, 5-methyl-3-(3-phenylpropyl)-

There total 7 articles about 2-Thiopheneheptanoic acid, 5-methyl-3-(3-phenylpropyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester (144313-88-2) → 7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-74-0)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In various solvent(s); at 210 ℃; for 4h; Yield given;

DOI:10.1021/jm00095a011

Reference yield:

ethyl 6-(chloroformyl)hexanoate (14794-32-2) → 7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-74-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: H₂NNH₂*H₂₀, KOH / various solvent(s) / 4 h / 210 °C

With potassium hydroxide; tin(IV) chloride; hydrazine hydrate; In 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

Reference yield:

2-methyl-4-thiophenecarboxaldehyde (29421-72-5) → 7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-74-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) Mg / 1.) THF, 0 deg C, 2.) THF, reflux, 1 h

2: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 1 h / Ambient temperature

3: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

4: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

5: H₂NNH₂*H₂₀, KOH / various solvent(s) / 4 h / 210 °C

With potassium hydroxide; sodium acetate; tin(IV) chloride; hydrazine hydrate; magnesium; pyridinium chlorochromate; In dichloromethane; 1,2-dichloro-ethane;

DOI:10.1021/jm00095a011

upstream raw materials:

7-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester

ethyl 6-(chloroformyl)hexanoate

2-methyl-4-thiophenecarboxaldehyde

1-phenyl-2-bromoethane