29421-72-5

Basic information

• Product Name: 5-Methylthiophene-3-carbaldehyde
• Synonyms: 5-Methylthiophene-3-carbaldehyde
• CAS NO: 29421-72-5
• Molecular Formula: C₆H₆OS
• Molecular Weight: 126.17624
• EINECS: -0
• Mol File: 29421-72-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-Methylthiophene-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylthiophene-3-carbaldehyde(29421-72-5)
• EPA Substance Registry System: 5-Methylthiophene-3-carbaldehyde(29421-72-5)

Safety Data

• Hazardous Substances Data: 29421-72-5(Hazardous Substances Data)

Usage

General Description

5-Methylthiophene-3-carbaldehyde is a chemical compound that is commonly used in the synthesis of various pharmaceuticals and agrochemicals. It is a yellow liquid with a strong and sweet odor, and it is known for its reactive nature. It is primarily used as an intermediate in the production of fine chemicals, serving as a key building block in the manufacturing of drugs and pesticides. Additionally, 5-Methylthiophene-3-carbaldehyde is employed in the development of fragrances and perfumes, as well as in the formulation of flavoring agents. Its unique structure and properties make it a valuable and versatile compound for use in various industrial processes.

Upstream product

• 498-62-4 3-thiophene carboxaldehyde 
• 74-88-4 methyl iodide 
• 29421-92-9 4-bromo-2-methylthiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 19156-50-4 5-methyl-thiophene-3-carboxylic acid 
• 207277-11-0 (5-methylthiophen-3-yl)methanol 

Downstream Products

• 1472655-15-4 C₂₉H₂₇NO₅S₂ 
• 1472655-14-3 C₂₉H₂₇NO₆S 
• 144313-89-3 2-Methyl-7-[5-methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester 
• 144313-88-2 7-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-yl]-7-oxo-heptanoic acid ethyl ester 
• 142423-07-2 6-[5-Methyl-3-(3-phenyl-propyl)-thiophen-2-ylsulfanyl]-hexanoic acid ethyl ester 
• 142422-81-9 2-methyl-7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid 
• 142422-82-0 2,2-dimethyl-7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid 
• 142422-76-2 6-<<5-methyl-3-(3-phenylpropyl)-2-thienyl>thio>hexanoic acid 
• 142422-74-0 7-<5-methyl-3-(3-phenylpropyl)-2-thienyl>heptanoic acid 
• 144313-87-1 1-(5-Methyl-thiophen-3-yl)-3-phenyl-propan-1-one 
• 142422-98-8 2-methyl-4-(3-phenylpropyl)thiophene 
• 78348-00-2 3-<2-(2'-bromo-4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxaldehyde 
• 78347-94-1 4-<2-(2'-bromo-4'-chlorophenyl)ethyl>-2-methylthiophene 
• 74168-85-7 3-<2-(4'-chlorophenyl)ethyl>-5-methyl-2-thiophenecarboxylic acid 

Relevant articles and documents

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking

Photoisomerizable diarylethenes equipped with triple bonds are promising building blocks for constructing bistable photocontrollable systems. Here we report on the design, synthesis and application of a cross-linking reagent which is based on a diarylethene core and features two strained cyclooctynes. High reactivity of the cyclooctyne rings in catalyst-free 1,3-dipolar cycloaddition reactions was suggested to stem from the additional strain imposed by the fused thiophene rings. This hypothesis was confirmed by quantum chemical calculations.

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

The present invention provides 1H-pyrazolo[4,3-b]pyridines of formula (I) as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.