2-cyano-N-(4-sulfamoylphenyl)acetamide

Base Information

• Chemical Name: 2-cyano-N-(4-sulfamoylphenyl)acetamide
• CAS No.: 32933-40-7
• Molecular Formula: C9H9 N3 O3 S
• Molecular Weight: 239.255
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID60368234
• Nikkaji Number: J3.184.736B
• Wikidata: Q82154627
• Pharos Ligand ID: 6KSDJACAR53Y
• ChEMBL ID: CHEMBL2337540
• Mol file: 32933-40-7.mol

Synonyms:2-cyano-N-(4-sulfamoylphenyl)acetamide;32933-40-7;2-Cyano-N-(4-sulfamoyl-phenyl)-acetamide;N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide;CHEMBL2337540;DTXSID60368234;HMS1723N09;BBL017242;BDBM50428849;MFCD01115985;STK442556;AKOS000115181;CCG-356952;2-cyano-N-(4-sulfamoylphenyl) acetamide;VS-05981;BB 0218819;CS-0451133;FT-0679398;EN300-01421;J-509220;Z56840023

Chemical Property of 2-cyano-N-(4-sulfamoylphenyl)acetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 121.43000
• Density: 1.482g/cm³
• LogP: 2.04028
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 239.03646233
• Heavy Atom Count: 16
• Complexity: 396

Purity/Quality:

98%Min ^*data from raw suppliers

N-[4-(Aminosulfonyl)phenyl]-2-cyanoacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)CC#N)S(=O)(=O)N

Technology Process of 2-cyano-N-(4-sulfamoylphenyl)acetamide

There total 3 articles about 2-cyano-N-(4-sulfamoylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

sulfanilamide (63-74-1) + ethyl 2-cyanoacetate (105-56-6) → N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (32933-40-7)

Guidance literature:

In m-xylene; Reflux;

DOI:10.1002/jccs.200900154

Reference yield:

sulfanilamide (63-74-1) + 1-cyanoacetyl-3,5-dimethylpyrazole (36140-83-7) → N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (32933-40-7)

Guidance literature:

In 1,4-dioxane;

DOI:10.1002/jhet.2576 DOI:10.2174/1570180814666170607144811

Reference yield:

→ N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (32933-40-7)

Guidance literature:

Cyanacetyl-3.5-dimethyl-pyrazol, 4-Amino-benzol-sulfonsaeure-amid;

upstream raw materials:

sulfanilamide

ethyl 2-cyanoacetate

1-cyanoacetyl-3,5-dimethylpyrazole

Downstream raw materials:

2-oxo-N’-phenyl-2-(4-sulfamoylphenylamino)acetohydrazonoyl cyanide

3-(2-chlorophenyl)-2-cyano-N-(4-sulfamoylphenyl)acrylamide

2-cyano-3-(2,4-dichlorophenyl)-N-(4-sulfamoylphenyl)acrylamide

2-cyano-3-(4-nitrophenyl)-N-(4-sulfamoylphenyl)acrylamide