Magnesium, bromo[2-[3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-

Base Information

Chemical Name:Magnesium, bromo[2-[3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-
CAS No.:142663-80-7
Molecular Formula:C17H29BrMgOSi
Molecular Weight:
Hs Code.:

Synonyms:

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Chemical Property of Magnesium, bromo[2-[3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-

Chemical Property:

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Technology Process of Magnesium, bromo[2-[3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]-

There total 1 articles about Magnesium, bromo[2-[3-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]propyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142663-80-7
<1-bromo-2-<3-<oxy>propyl>phenyl>magnesium

Guidance literature:

Reference yield:

: 142663-80-7
<1-bromo-2-<3-<oxy>propyl>phenyl>magnesium

: <1S-(1α,2α,3α,4α)>-2-<<3-<4-<<(4-cyclohexylbutyl)oxo>carbonyl>-2-oxazolyl>-7-oxabicyclo<2.2.1>hept-2-yl>methyl>benzenepropanoic acid

Guidance literature:: Multi-step reaction with 18 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 1 h, 2.) THF, 25 deg C, 6 days

2: H₂ / 20percent Pd(OH)2-C / acetic acid / 24 h / 25 °C / 760 Torr

3: pyridine / 16 h / 25 °C

4: CrO₃/H₂SO₄ / acetone / 0.75 h

5: NaOH / tetrahydrofuran; H₂O / 25 °C

6: 68.5 percent / HCl / 15 h / Ambient temperature

7: 82 percent / CrO₃, H₂SO₄ / acetone / 0.67 h / 25 °C

8: 1.) 1-hydroxybenzotriazole, Et₃N, 2.) dicyclohexylcarbodiimide / 1.) THF, 0 deg C, 5 min, 2.) THF, from 0 deg C to RT, 20 h

9: 77 percent / Ph₃P, diisopropylethylamine, CCl₄ / acetonitrile; CH₂Cl₂ / 2.5 h / Ambient temperature

10: 65 percent / CuBr₂, DBU / ethyl acetate; CHCl₃ / 22 h

11: 94 percent / H₂ / 20percent Pd(OH)2-C / ethyl acetate / 3 h / 760 Torr

12: oxalyl chloride, DMF / CH₂Cl₂ / 0.67 h / Ambient temperature

13: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

14: 97 percent / LiOH / tetrahydrofuran; H₂O / 2 h / Ambient temperature

15: 85 percent / K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

16: glacial acetic acid, acetic anhydride, sodium nitrite / 3.25 h

17: 105 mg / dioxane / 2 h / 95 °C

18: 79 percent / H₂ / 10percent Pd-C / ethyl acetate / 760 Torr

With pyridine; chromium(VI) oxide; hydrogenchloride; tetrachloromethane; lithium hydroxide; sodium hydroxide; oxalyl dichloride; sulfuric acid; ethylmagnesium bromide; hydrogen; acetic anhydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; triphenylphosphine; copper(ll) bromide; sodium nitrite; palladium on activated charcoal; palladium hydroxide - carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm00062a013

Reference yield:

: 142663-80-7
<1-bromo-2-<3-<oxy>propyl>phenyl>magnesium

: 139067-88-2
SQ 33961

Guidance literature:: Multi-step reaction with 14 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 1 h, 2.) THF, 25 deg C, 6 days

2: H₂ / 20percent Pd(OH)2-C / acetic acid / 24 h / 25 °C / 760 Torr

3: pyridine / 16 h / 25 °C

4: CrO₃/H₂SO₄ / acetone / 0.75 h

5: NaOH / tetrahydrofuran; H₂O / 25 °C

6: 68.5 percent / HCl / 15 h / Ambient temperature

7: 82 percent / CrO₃, H₂SO₄ / acetone / 0.67 h / 25 °C

8: 1.) 1-hydroxybenzotriazole, Et₃N, 2.) dicyclohexylcarbodiimide / 1.) THF, 0 deg C, 5 min, 2.) THF, from 0 deg C to RT, 20 h

9: 77 percent / Ph₃P, diisopropylethylamine, CCl₄ / acetonitrile; CH₂Cl₂ / 2.5 h / Ambient temperature

10: 65 percent / CuBr₂, DBU / ethyl acetate; CHCl₃ / 22 h

11: 94 percent / H₂ / 20percent Pd(OH)2-C / ethyl acetate / 3 h / 760 Torr

12: oxalyl chloride, DMF / CH₂Cl₂ / 0.67 h / Ambient temperature

13: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

14: 97 percent / LiOH / tetrahydrofuran; H₂O / 2 h / Ambient temperature

With pyridine; chromium(VI) oxide; hydrogenchloride; tetrachloromethane; lithium hydroxide; sodium hydroxide; oxalyl dichloride; sulfuric acid; ethylmagnesium bromide; hydrogen; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; triphenylphosphine; copper(ll) bromide; palladium hydroxide - carbon; In tetrahydrofuran; dichloromethane; chloroform; water; acetic acid; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00062a013