3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

Base Information

Chemical Name:3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid
CAS No.:142758-00-7
Molecular Formula:C₁₇H₂₂O₄
Molecular Weight:290.359
Hs Code.:

Synonyms:3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

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Chemical Property of 3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

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Technology Process of 3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

There total 12 articles about 3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142757-90-2
[1S-(1α,2α,3α,4α)]-2-[[3-[(Acetyloxy)methyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]benzenepropanoic acid

: 142758-00-7
3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 25 ℃; for 0.5h;
DOI:10.1021/jm00113a030

Reference yield:

: 404575-34-4
7-oxabicyclo<2.2.1>heptane tetrahydrofuranol

: 142758-00-7
3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 1 h, 2.) THF, 25 deg C, 6 days

2: H₂ / 20percent Pd(OH)2-C / acetic acid / 24 h / 25 °C / 760 Torr

3: pyridine / 16 h / 25 °C

4: CrO₃/H₂SO₄ / acetone / 0.75 h

5: NaOH / tetrahydrofuran; H₂O / 25 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; sulfuric acid; ethylmagnesium bromide; hydrogen; palladium hydroxide - carbon; In tetrahydrofuran; water; acetic acid; acetone;
DOI:10.1021/jm00062a013

Reference yield:

: 142663-80-7
<1-bromo-2-<3-<oxy>propyl>phenyl>magnesium

: 142758-00-7
3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl)-phenyl]-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 1 h, 2.) THF, 25 deg C, 6 days

2: H₂ / 20percent Pd(OH)2-C / acetic acid / 24 h / 25 °C / 760 Torr

3: pyridine / 16 h / 25 °C

4: CrO₃/H₂SO₄ / acetone / 0.75 h

5: NaOH / tetrahydrofuran; H₂O / 25 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; sulfuric acid; ethylmagnesium bromide; hydrogen; palladium hydroxide - carbon; In tetrahydrofuran; water; acetic acid; acetone;
DOI:10.1021/jm00062a013