2H-Indol-2-one, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-1,3-dimethyl-3-(meth ylthio)-

Base Information

• Chemical Name: 2H-Indol-2-one, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-1,3-dimethyl-3-(meth ylthio)-
• CAS No.: 142720-93-2
• Molecular Formula: C18H15ClF3NO2S
• Molecular Weight: 401.837
• Mol file: 142720-93-2.mol

Synonyms:

Chemical Property of 2H-Indol-2-one, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-1,3-dimethyl-3-(meth ylthio)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Indol-2-one, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-1,3-dimethyl-3-(meth ylthio)-

There total 5 articles about 2H-Indol-2-one, 4-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-1,3-dimethyl-3-(meth ylthio)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-fluoro benzotrifluoride (78068-85-6) → 4-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-1,3-dimethyl-3-(methylthio)indolin-2-one (142720-93-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / K₂CO₃ / dimethylformamide / 48 h / 100 °C

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 17 percent / p-toluenesulfonic acid / toluene / Heating

4: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

5: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

With chlorine; sodium hydride; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo00043a044

Reference yield:

m-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>aniline (78747-70-3) → 4-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-1,3-dimethyl-3-(methylthio)indolin-2-one (142720-93-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

2: 17 percent / p-toluenesulfonic acid / toluene / Heating

3: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

4: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

With chlorine; sodium hydride; triethylamine; toluene-4-sulfonic acid; In toluene;

DOI:10.1021/jo00043a044

Reference yield:

[2-Amino-6-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester (1026509-54-5) → 4-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-1,3-dimethyl-3-(methylthio)indolin-2-one (142720-93-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 17 percent / p-toluenesulfonic acid / toluene / Heating

2: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

3: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

With sodium hydride; toluene-4-sulfonic acid; In toluene;

DOI:10.1021/jo00043a044

upstream raw materials:

3-chloro-4-fluoro benzotrifluoride

m-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>aniline

4-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-(methylthio)-indolin-2-one

[2-Amino-6-(2-chloro-4-trifluoromethyl-phenoxy)-phenyl]-methylsulfanyl-acetic acid ethyl ester

Downstream raw materials:

4-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-1,3-dimethylindolin-2-one