78068-85-6

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-fluorobenzotrifluoride is used as a reagent for the synthesis of β-substituted 3-(4-aryloxyaryl)propanoic acid, which are known as GPR40 agonists. These agonists play a crucial role in the development of drugs targeting the treatment of type 2 diabetes and metabolic disorders. 3-Chloro-4-fluorobenzotrifluoride's ability to form stable intermediates and facilitate specific chemical transformations makes it an essential component in the synthesis process.

InChI:InChI=1/C6F10/c7-2-1(5(12,13)14)3(8,9)6(15,16)4(2,10)11

Upstream product

• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 

Downstream Products

• 710982-51-7 1-benzyl-5-(2-chloro-4-trifluoromethyl-phenoxy)-1H-indole 
• 905725-11-3 C₁₆H₁₀ClF₃O₂ 
• 80175-36-6 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzaldehyde 
• 76338-73-3 2-(2-chloro-α,α,α-trifluoro-p-toluidino)-3-methylbutyric acid 
• 42874-01-1 nitro 4-[2-chloro-4-(trifluoromethyl)-phenoxy] benzene 
• 1030829-55-0 2-chloro-1-(4-iodophenoxy)-4-(trifluoromethyl)benzene 
• 1055361-67-5 4-(2-chloro-4-trifluoromethylphenoxy)-3-methoxybenzaldehyde 
• 1428626-85-0 C₁₃H₇Cl₂F₃O₂ 
• 161462-33-5 1-cyano-2-methylthio-4-trifluoromethylbenzene 
• 1813-33-8 2-chloro-4-trifluoromethyl-benzonitril 
• 55407-28-8 p-[(2-chloro-α,α,α-trifluoro-p-tolyl)oxy]aniline 
• 1312787-86-2 5-[4-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]isothiazol-3-ol 1-oxide 
• 114298-69-0 (R)-2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid 

Relevant academic research and scientific papers

Method for preparation of fluoroamine cyanchrysanthemic acid with non-metal catalyst

The invention discloses a method for preparation of fluoroamine cyanchrysanthemic acid with non-metal catalyst. The method includes the steps of: adding a catalyst into 3, 4-dichloro-benzotrifluoride and potassium fluoride in an organic solvent at 0-200DE

On the Solubility of Fluoride Ion in Sulfolane, the Limiting Factor for Efficient Aromatic Nucleophilic Fluorinations

The reaction of 3,4-dichlorobenzotrifluoride with KF and a quaternary onium salt (the "catalyst" in sulfolane was used as a model reaction to clarify the mode of action of the catalyst and to find the best experimental conditions for this and related synt

AROMATIC FLUORINE CHEMISTRY. PART 1. 3,4-DIFLUOROBENZOIC ACID AND DERIVATIVES VIA 3,4-DIFLUOROBENZOTRIFLUORIDE

The preparation of 3,4-difluorobenzotrifluoride from 3,4-dichlorobenzotrifluoride by a KF exchange reaction is described.The conversion of 3,4-difluorobenzotrifluoride to 3,4-difluorobenzoic acid and derivatives is also reported.

A Facile Preparation of Fluoropyridines from Aminopyridines via Diazotation and Fluorodediazoniation in HF or HF-Pyridine Solutions

Fluoropyridines were prepared in high yields by dizotation of aminopyridines in HF or HF-pyridine solutions, followed by dediazoniation in situ at 20-60 deg C.

THE FLUORINATION OF ORGANIC SUBSTRATES WITH TETRAPHENYLPHOSPHONIUM HYDROGENDIFLUORIDE

Tetraphenylphosphonium hydrogendifluoride acts as a powerful source of F- in various reactions with organic substrates to give fluorine containing products.

Process for the preparation substituted anilino acids

Anilino acids of the formula STR1 wherein R is H or a metal cation; R2 is hydrogen or lower alkyl of 1 to 5 carbon atoms, lower alkenyl of 2 to 5 carbon atoms, lower haloalkyl of 1-4 carbon atoms, lower haloalkenyl of 2 to 4 carbon atoms, or lower cycloalkyl of 3 to 4 carbon atoms, Y is hydrogen, chloro, methyl group, or trifluoromethyl group, and X is hydrogen, chloro, or fluoro are prepared by reaction of an aryl halide of the formula STR2 where X1 is chloro or fluoro and X and Y are as defined above with the proviso that when X1 is chloro, X is hydrogen or chloro, and when X and Y are both chloro, X1 is fluoro with an α-amino acid of the formula STR3 where R and R2 are as defined above.