78068-85-6

Basic information

• Product Name: 3-Chloro-4-fluorobenzotrifluoride
• Synonyms: 2-Chloro-1-fluoro-4-(trifluoromethyl)benzene, 3-Chloro-alpha,alpha,alpha,4-tetrafluorotoluene;3-chloro -4-fluorine three fluorine toluene;3-4 - three fluorine fluorine chlorine - toluene;3-chloro-4-fluorotrifluorotoluene;3-Chloro-Α,Α,Α,4-Tetrafluorotoluene;2-CHLORO-1-FLUORO-4-(TRIFLUOROMETHYL)BENZENE;1-chloro-2-fluoro-5-(trifluoromethyl)-benzene;3-CHLORO-4-FLUORO-1-(TRIFLUOROMETHYL)BENZENE
• CAS NO: 78068-85-6
• Molecular Formula: C₇H₃ClF₄
• Molecular Weight: 198.55
• EINECS: -0
• Product Categories: Fluorine series;Trifluoromethylbenzene serise;Aromatic Hydrocarbons (substituted) & Derivatives;API intermediates;organofluorine compounds
• Mol File: 78068-85-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 137℃
• Flash Point: 42°(108°F)
• Appearance: /
• Density: 1,49 g/cm3
• Vapor Pressure: 1040mmHg at 25°C
• Refractive Index: 1.4355
• Storage Temp.: 0-10°C
• Solubility: Chloroform, Methanol
• BRN: 4309386
• CAS DataBase Reference: 3-Chloro-4-fluorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-4-fluorobenzotrifluoride(78068-85-6)
• EPA Substance Registry System: 3-Chloro-4-fluorobenzotrifluoride(78068-85-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• RIDADR: 1993
• TSCA: Yes
• HazardClass: 3
• PackingGroup: Ⅲ
• Hazardous Substances Data: 78068-85-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

Uses

3-Chloro-4-fluorobenzotrifluoride acts as a reagent in the synthesis of β-substituted 3-(4-aryloxyaryl)propanoic acid as GPR40 agonists.

InChI:InChI=1/C6F10/c7-2-1(5(12,13)14)3(8,9)6(15,16)4(2,10)11

Upstream product

• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 39885-50-2 2-chloro-4-(trifluoromethyl)aniline 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 

Downstream Products

• 78747-70-3 m-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>aniline 
• 79576-17-3 m-[(2,-Chloro-α,α,α-trifluoro-p-tolyl)oxy]aniline 
• 76338-73-3 2-(2-chloro-α,α,α-trifluoro-p-toluidino)-3-methylbutyric acid 
• 1022980-20-6 methyl {5-[2-chloro-4-(trifluoromethyl)phenoxy]-3-oxo-2,3-dihydro-1H-isoindol-1-yl}acetate 
• 1022980-16-0 {5-[2-chloro-4-(trifluoromethyl)phenoxy]-3-oxo-2,3-dihydro-1H-inden-1-yl}acetate 
• 1022980-17-1 {5-[2-chloro-4-(trifluoromethyl)phenoxy]-3-oxo-2,3-dihydro-1H-inden-1-yl}acetate 
• 1022980-01-3 C₁₉H₁₆ClF₃O₃S 
• 261763-02-4 3-chloro-2-fluoro-5-(trifluoromethyl)benzaldehyde 
• 1198578-80-1 sodium (3-chloro-2-fluoro-5-trifluoromethyl-phenyl)-hydroxy-methanesulfonate 
• 129931-45-9 3-chloro-2-fluoro-5-(trifluoromethyl)benzoic acid 
• 1432445-29-8 1-(4-(2-chloro-4-(trifluoromethyl)phenyl)piperazin-1-yl)-4-(thiophen-2-yl)butan-1-one 
• 114298-69-0 (R)-2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutanoic acid 
• 142720-94-3 ethyl 5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-α,3-dimethyl-3-(methylthio)-2-oxo-1-indolineacetate 
• 142720-89-6 ethyl 5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-α-methyl-3-(methylthio)-2-oxo-3-indolineacetate 

Relevant articles and documents

Method for preparation of fluoroamine cyanchrysanthemic acid with non-metal catalyst

The invention discloses a method for preparation of fluoroamine cyanchrysanthemic acid with non-metal catalyst. The method includes the steps of: adding a catalyst into 3, 4-dichloro-benzotrifluoride and potassium fluoride in an organic solvent at 0-200DE

On the Solubility of Fluoride Ion in Sulfolane, the Limiting Factor for Efficient Aromatic Nucleophilic Fluorinations

The reaction of 3,4-dichlorobenzotrifluoride with KF and a quaternary onium salt (the "catalyst" in sulfolane was used as a model reaction to clarify the mode of action of the catalyst and to find the best experimental conditions for this and related synt

A Facile Preparation of Fluoropyridines from Aminopyridines via Diazotation and Fluorodediazoniation in HF or HF-Pyridine Solutions

Fluoropyridines were prepared in high yields by dizotation of aminopyridines in HF or HF-pyridine solutions, followed by dediazoniation in situ at 20-60 deg C.