2H-Indol-2-one, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-3-methyl-1-(2-propyn yl)-

Base Information

Chemical Name:2H-Indol-2-one, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-3-methyl-1-(2-propyn yl)-
CAS No.:142721-07-1
Molecular Formula:C19H13ClF3NO2
Molecular Weight:379.766
Hs Code.:

Synonyms:

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Chemical Property of 2H-Indol-2-one, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-3-methyl-1-(2-propyn yl)-

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Technology Process of 2H-Indol-2-one, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-3-methyl-1-(2-propyn yl)-

There total 7 articles about 2H-Indol-2-one, 5-[2-chloro-4-(trifluoromethyl)phenoxy]-1,3-dihydro-3-methyl-1-(2-propyn yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 142720-99-8
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-3-(methylthio)-1-(2-propynyl)indolin-2-one

: 142721-06-0
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

: 142721-07-1
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-1-(2-propynyl)indolin-2-one

Guidance literature:: With zinc; In acetic acid; for 1h; Heating;
DOI:10.1021/jo00043a044

Reference yield:

: 123-30-8
4-amino-phenol

: 142721-07-1
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-1-(2-propynyl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 66 h / 100 °C

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 49 percent / p-toluenesulfonic acid / toluene / Heating

4: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

5: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

6: 55 percent / zinc dust / acetic acid / 1 h / Heating

With chlorine; sodium hydride; potassium carbonate; triethylamine; zinc; toluene-4-sulfonic acid; In acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00043a044

Reference yield:

: 78068-85-6
3-chloro-4-fluoro benzotrifluoride

: 142721-07-1
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-1-(2-propynyl)indolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 66 h / 100 °C

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 49 percent / p-toluenesulfonic acid / toluene / Heating

4: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

5: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

6: 55 percent / zinc dust / acetic acid / 1 h / Heating

With chlorine; sodium hydride; potassium carbonate; triethylamine; zinc; toluene-4-sulfonic acid; In acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00043a044