(4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one

Base Information

Chemical Name:(4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one
CAS No.:142763-11-9
Molecular Formula:C12H15NO4
Molecular Weight:237.255
Hs Code.:
DSSTox Substance ID:DTXSID301220270
Nikkaji Number:J2.533.013G

Synonyms:142763-11-9;(4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one;DTXSID301220270;(4S)-4-[(3,4-Dimethoxyphenyl)methyl]-2-oxazolidinone

Suppliers and Price of (4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:237.10010796
Heavy Atom Count:17
Complexity:271

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC2COC(=O)N2)OC
Isomeric SMILES:COC1=C(C=C(C=C1)C[C@H]2COC(=O)N2)OC

Technology Process of (4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one

There total 4 articles about (4S)-4-(3,4-Dimethoxybenzyl)oxazolidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 138908-56-2
(S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester

: 142763-11-9
(S)-4-(3,4-dimethoxybenzyl)oxazolidin-2-one

Guidance literature:: (S)-(+)-2-tert-butoxycarbonylamino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester; With lithium borohydride; In tetrahydrofuran;

With thionyl chloride; In tetrahydrofuran;
DOI:10.1055/s-0031-1290335

Reference yield: 81.0%

: 105779-71-3
(S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester

: 142763-11-9
(S)-4-(3,4-dimethoxybenzyl)oxazolidin-2-one

Guidance literature:: With thionyl chloride; In tetrahydrofuran; at 25 ℃; for 4h;
DOI:10.1002/ejoc.200700366

Reference yield:

: 59-92-7,90638-38-3
levodopa

: 142763-11-9
(S)-4-(3,4-dimethoxybenzyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 1,4-dioxane; water / 18.5 h / 0 - 20 °C

2: potassium carbonate / acetone / 48 h / Reflux

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 0.5 h / Reflux

4: sodium hydride / tetrahydrofuran / Reflux

With lithium aluminium tetrahydride; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; acetone;