eudistomin M

Base Information

• Chemical Name: eudistomin M
• CAS No.: 88704-39-6
• Molecular Formula: C₁₅H₁₁N₃O
• Molecular Weight: 249.272
• Hs Code.: 2933990090
• Mol file: 88704-39-6.mol

Synonyms:EudistominM; Eudistomine M

Chemical Property of eudistomin M

Chemical Property:

• Vapor Pressure: 6.04E-16mmHg at 25°C
• Boiling Point: 619.6°C at 760 mmHg
• Flash Point: 328.5°C
• PSA: 64.70000
• Density: 1.455g/cm³
• LogP: 3.41680

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of eudistomin M

There total 12 articles about eudistomin M which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-methoxy-1-(pyrrol-2-yl)-β-carboline (108061-57-0) → eudistomin M (88704-39-6)

Guidance literature:

With boron tribromide; In dichloromethane; 1,2-dichloro-ethane; for 0.5h; Heating;

DOI:10.1021/ja00245a031

Reference yield:

6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acid (17952-63-5) → eudistomin M (88704-39-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 97 percent / HCl / Ambient temperature

2: 77 percent / conc. aq. NH₄OH / Ambient temperature

3: 70 percent / 5percent Pd/C / xylene / 2 h / Heating

4: 65 percent / POCl₃, pyridine / dimethylformamide / 1 h / 0 °C

5: 75 percent / tetrahydrofuran / 2 h / Ambient temperature

6: 69 percent / ammonium acetate / acetic acid / 3 h / Heating

7: 72 percent / boron tribromide / CH₂Cl₂; 1,2-dichloro-ethane / 0.5 h / Heating

With pyridine; ammonium acetate; hydrogenchloride; ammonium hydroxide; boron tribromide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene;

DOI:10.1021/ja00245a031

Reference yield:

1-carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline (108061-51-4) → eudistomin M (88704-39-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / 5percent Pd/C / xylene / 2 h / Heating

2: 65 percent / POCl₃, pyridine / dimethylformamide / 1 h / 0 °C

3: 75 percent / tetrahydrofuran / 2 h / Ambient temperature

4: 69 percent / ammonium acetate / acetic acid / 3 h / Heating

5: 72 percent / boron tribromide / CH₂Cl₂; 1,2-dichloro-ethane / 0.5 h / Heating

With pyridine; ammonium acetate; boron tribromide; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; xylene;

DOI:10.1021/ja00245a031

upstream raw materials:

6-methoxy-1-(pyrrol-2-yl)-β-carboline

6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acid

1-cyano-6-methoxy-β-carboline

1-carbamoyl-6-methoxy-β-carboline

Refernces