ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE
• CAS No.: 7238-62-2
• Molecular Formula: C7H8 Cl N O2 S
• Molecular Weight: 205.665
• Hs Code.: 2934100090
• Mol file: 7238-62-2.mol

Synonyms:2-Chloro-4-methyl-5-ethoxycarbonylthiazole;2-Chloro-4-methylthiazole-5-carboxylic acid ethyl ester; Ethyl2-chloro-4-methyl-1,3-thiazole-5-carboxylate

Chemical Property of ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.56E-12mmHg at 25°C
• Melting Point: 46 °C
• Boiling Point: 116℃
• PKA: -0.10±0.10(Predicted)
• Flash Point: 277.9°C
• PSA: 67.43000
• Density: 1.51g/cm³
• LogP: 2.28160

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Chloro-4-methylthiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE

There total 11 articles about ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

tert.-butylnitrite (540-80-7) + ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) → ethyl 2-chloro-4-methylthiazole-5-carboxylate (7238-62-2)

Guidance literature:

With hydrogenchloride; copper(I) chloride; In water; acetonitrile;

Reference yield: 94.0%

tert.-butylnitrite (540-80-7) + ethyl-2-amino-4-methylthiazole-5-carboxylate (7210-76-6) + water (7732-18-5) → ethyl 2-chloro-4-methylthiazole-5-carboxylate (7238-62-2)

Guidance literature:

With hydrogenchloride; copper(I) chloride; In acetonitrile;

Reference yield: 91.0%

4-methyl-2-thiazolone-5-carboxylic acid ethyl ester (40235-78-7) → ethyl 2-chloro-4-methylthiazole-5-carboxylate (7238-62-2)

Guidance literature:

With trichlorophosphate; Heating;

upstream raw materials:

tetrahydrofuran

2-chloro-4,5-dimethyl-1,3-thiazole

2-(4,5-dimethyl-thiazol-2-ylmercapto)-4-methyl-thiazole-5-carboxylic acid ethyl ester

4-methyl-2-thiazolone-5-carboxylic acid ethyl ester

Downstream raw materials:

4-methyl-2-thiazolone-5-carboxylic acid ethyl ester

3-Methyl-4-oxo-4H-1,9-dithia-3a,10-diaza-cyclopenta[b]fluorene-2-carboxylic acid ethyl ester

3-Methyl-4-oxo-5,6,7,8-tetrahydro-4H-1,9-dithia-3a,10-diaza-cyclopenta[b]fluorene-2-carboxylic acid ethyl ester

3-Methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]thieno[2,3-d]pyrimidine-2-carboxylic acid ethyl ester