40235-78-7

Upstream product

• 7238-62-2 ethyl 2-chloro-4-methylthiazole-5-carboxylate 
• 626-34-6 ethyl aminocrotonate 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 16687-42-6 ammonium thiocarbamate 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 626-34-6 ethyl 3-aminobut-2-enoate 
• 65573-12-8 4-chloro-5H-1,2,3-dithiazole-5-one 
• 637-98-9 S-ethyl thiocarbamate 
• 13176-46-0 4-bromoethyl acetoacetate 
• 156498-55-4 ethyl N-acetyl-5-methyl-1,3-oxathiol-2-imine-4-carboxylate 

Downstream Products

• 7238-62-2 ethyl 2-chloro-4-methylthiazole-5-carboxylate 
• 1400661-12-2 2-[3-(3-Methoxy-phenyl)-propoxy]-4-methyl-thiazole-5-carboxylic acid ethyl ester 
• 1400661-13-3 2-[3-(3-Hydroxy-phenyl)-propoxy]-4-methyl-thiazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

AMINOPHENYLCYCLOPROPYL CARBOXYLIC ACIDS AND DERIVATIVES AS AGONISTS TO GPR40

The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.

4-Chloro-5H-1,2,3-dithiazol-5-one: A good α-thiocyanating agent for α,β-unsaturated β-amino esters

Treatment of 4-chloro-5H- 1,2,3-dithiazol-5-one with 3-alkyl (or aryl)- 3-amino-2-propenoate esters in DMSO at 120°C gave the corresponding 2- thiocyanated esters 4 (major) and 5-alkoxycarbonyl-4-alkyl (or aryl)-4- thiazolin-2-ones 5 (minor), whereas the

Pyrazolecarboxylic acid derivatives and plant disease control agent

The present invention provides a plant disease control agent containing as active ingredient one or more compounds of the formula [1]A--COOR 1 [1]whereinR 1 represents a hydrogen atom or a C 1 -C 4 alkyl group, andA represents a group of the formula (A-1) or (A-2) STR1 R 2 represents a C 1 -C 4 alkyl group, R 3 represents a C 1 -C 4 alkyl group,R 4 represents a halogen atom or a C 1 -C 4 alkyl group, andR 5 represents a C 1 -C 4 alkyl group.Further, the compound of A-1 in the formula [1] in which R 3 is a halogen atom is also included in the present invention.

Pseudohalogen chemistry. XI. Some aspects of the chemistry of octhiocyanato-β-dicarbonyl compounds

Enolised α-thiocyanato-β-dicarbonyl compounds dimerise in ethanol at room temperature to give tautomeric 4,5-disubstituted 2-amino- and 2-acetamido-thiazoles by a C-S-C + C-N cyclisation. Tautomerism is due to the unusual 4-(β-dicarbonyl-α-thio) substituent. Competing intramolecular cyclisations lead to minor amounts of heterocycles containing the thiazole and/or oxathiole ring systems.

Synthesis of Heterocyclic Compounds from 0-Aminobenzenethiol and Ammonium Thiocarbamate

The reaction of o-aminobenzenethiol with carbonyl sulfide in the presence of triethylamine afforded an alternate route for the synthesis of 2-benzothiazolinone (1) in 97-98percent yield.The reaction of ammonium thiocarbamate (2) with 2-chlorocyclohexanone furnished the novel 4,5,6,7-tetrahydro-2-benzothiazolinone (3). 3-Ethoxy-2H-1,4-benzothiazin-2-one (7) was prepared by the reaction of o-aminobenzenethiol with diethyl oxalate.Possible pathways and supporting nmr, ir and mass spectra are discussed.

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2-Thiazolone-5-carboxylic acid ester fungicidal agents

Fungicidal compositions containing, and methods of combating fungi using, 2-thiazolone-5-carboxylic acid ester fungicidal agents of the formula SPC1 In which R1 is hydrogen; alkyl of up to 12 carbon atoms optionally substituted by phenyl, halop

Novel thiazole derivatives

Novel compounds of the formula EQU1 wherein X is selected from the group consisting of oxygen and sulfur, X1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, cyano and EQU2 Y1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms and amino, n is 0, 1 or 2, X2 is selected from the group consisting of hydrogen, chlorine, bromine, alkyl of 1 to 6 carbon atoms, cyano and EQU3 R is alkyl of 1 to 6 carbon atoms, R1 is selected from the group consisting of alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms and EQU4 and R2 and R3 are selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms with the proviso that X1 is other than alkyl when X2 is alkyl or hydrogen, having insecticidal, nematocidal and acaricidal properties.