methyl 2-cyclobutylideneacetate

Base Information

• Chemical Name: methyl 2-cyclobutylideneacetate
• CAS No.: 143140-39-0
• Molecular Formula: C7H10O2
• Molecular Weight: 126.155
• Hs Code.: 2916209090
• Mol file: 143140-39-0.mol

Synonyms:methyl cyclobutylideneacetate;Cyclobutylidene-acetic acid methyl ester;

Chemical Property of methyl 2-cyclobutylideneacetate

Chemical Property:

• PSA: 26.30000
• LogP: 1.26970
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

methyl2-cyclobutylideneacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-cyclobutylideneacetate

There total 2 articles about methyl 2-cyclobutylideneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclobutanone (1191-95-3) + phosphonoacetic acid trimethyl ester (40962-37-6) → methyl 2-cyclobutylideneacetate (143140-39-0)

Guidance literature:

phosphonoacetic acid trimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; for 1h; Ice cooling;

cyclobutanone; In tetrahydrofuran; at 20 ℃; Ice cooling;

Reference yield: 73.0%

cyclobutanone (1191-95-3) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl 2-cyclobutylideneacetate (143140-39-0)

Guidance literature:

In benzene; for 48h; Heating;

DOI:10.1016/S0040-4020(01)89026-8

Reference yield: 36.0%

C17H16N2O3S + methyl 2-cyclobutylideneacetate (143140-39-0) → methyl 2-(1-((4-((2-methylquinolin-4-yl)methoxy)phenyl)sulfonamido)cyclobutyl)acetate

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2017.07.054

upstream raw materials:

cyclobutanone

methyl (triphenylphosphoranylidene)acetate

phosphonoacetic acid trimethyl ester

Downstream raw materials:

benzyl 3-(1-(3-(2-cyclobutylideneacetamido)benzoyl)piperidin-4-yl)benzylcarbamate

benzyl 3-(1-(3-(2-hydroxy-2-(1-hydroxycyclobutyl)acetamido)benzoyl)piperidin-4-yl)benzylcarbamate

methyl 2-(1-aminocyclobutyl)acetate

Refernces

• 1、 -. "PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO". Paragraph 0622; 0623. . Retrieved 2016/05/02.
• 2、 -. "BICYCLIC -AMINO ACID DERIVATIVE". Page/Page column 52; 53. . Retrieved 2010/06/17.