4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

Base Information

Chemical Name:4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid
CAS No.:132785-32-1
Molecular Formula:C₁₃H₁₅NO₅
Molecular Weight:265.266
Hs Code.:
DSSTox Substance ID:DTXSID50157795
Nikkaji Number:J1.503.290A
Wikidata:Q83025955
ChEMBL ID:CHEMBL351031
Mol file:132785-32-1.mol

Synonyms:4-(2-hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid;HFPA

Suppliers and Price of 4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

Chemical Property:

Vapor Pressure:1.09E-10mmHg at 25°C
Boiling Point:496.9°Cat760mmHg
Flash Point:254.3°C
PSA：106.86000
Density:1.382g/cm³
LogP:0.95190
XLogP3:-1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:265.09502258
Heavy Atom Count:19
Complexity:359

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(C(N1)C(=O)O)CC(=O)O)C2=CC=CC=C2O
Isomeric SMILES:C1[C@@H]([C@@H]([C@H](N1)C(=O)O)CC(=O)O)C2=CC=CC=C2O

Technology Process of 4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid

There total 2 articles about 4-(2-Hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136226-30-7
(2S,3S,4S)-3-Carboxymethyl-4-(2-hydroxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 132785-32-1
HFPA

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether; trifluoroacetic acid; at 0 ℃; Yield given;
DOI:10.1016/S0040-4039(00)97239-3

Reference yield:

: 126891-19-8
(2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 132785-32-1
HFPA

Guidance literature:: Multi-step reaction with 2 steps

1: KOH, H₂O / methanol

2: TMSOTf, PhSMe, TFA / 0 °C

With potassium hydroxide; trimethylsilyl trifluoromethanesulfonate; methyl-phenyl-thioether; water; trifluoroacetic acid; In methanol;
DOI:10.1016/S0040-4039(00)97239-3