(2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Base Information

• Chemical Name: (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester
• CAS No.: 126891-19-8
• Molecular Formula: C₂₃H₂₅NO₇
• Molecular Weight: 427.454

Synonyms:(2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Chemical Property of (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

Chemical Property:

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Technology Process of (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

There total 1 articles about (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + (3S,3aS,9bS)-5-Oxo-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindole-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester (126891-18-7) → (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126891-19-8)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1) CH₂Cl₂ 2) ether;

DOI:10.1016/S0040-4039(00)97239-3

Reference yield: 77.0%

trifluoromethylsulfonic anhydride (358-23-6) + (2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126891-19-8) → methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate (166326-80-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 53.0%

(2S,3S,4S)-4-(2-Hydroxy-phenyl)-3-methoxycarbonylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester (126891-19-8) → methyl (2S,3S,4S)-benzyloxycarbonyl-4-(2-hydroxy-5-iodophenyl)-2-methoxycarbonyl-3-pyrrolidineacetate (166326-76-7)

Guidance literature:

With chloroamine-T; sodium iodide; In N,N-dimethyl-formamide; for 1.5h; Ambient temperature;

upstream raw materials:

diazomethane

(3S,3aS,9bS)-5-Oxo-1,3,3a,4,5,9b-hexahydro-benzo[e]isoindole-2,3-dicarboxylic acid 2-benzyl ester 3-methyl ester

Downstream raw materials:

(2S,3S,4S)-3-Carboxymethyl-4-(2-hydroxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

(2S,3S,4S)-3-Methoxycarbonylmethyl-4-(2-methoxy-phenyl)-pyrrolidine-2-carboxylic acid methyl ester

methyl (2S,3S,4S)-4-(2-trifluoromethanesulfonyloxyphenyl)-1,2-dimethoxycarbonyl-3-pyrrolidine acetate

methyl (2S,3S,4S)-benzyloxycarbonyl-4-(2-hydroxy-5-iodophenyl)-2-methoxycarbonyl-3-pyrrolidineacetate

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