2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde

Base Information

Chemical Name:2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde
CAS No.:143207-64-1
Molecular Formula:C₁₃H₂₀O₃Si
Molecular Weight:252.386
Hs Code.:
European Community (EC) Number:958-585-1

Synonyms:2-[(tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde;EN300-28254000;143207-64-1

Suppliers and Price of 2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde

Chemical Property:

Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:252.11817103
Heavy Atom Count:17
Complexity:270

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=CC=CC(=C1C=O)O

Technology Process of 2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde

There total 1 articles about 2-[(Tert-butyldimethylsilyl)oxy]-6-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 387-46-2
2,6-dihydroxybenzaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: 143207-64-1
6-tert-butyldimethylsilyloxy-2-hydroxybenzaldehyde

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 1h; Ambient temperature;
DOI:10.1248/cpb.40.1130

Reference yield: 13.0%

: 1449-46-3
benzyltriphenylphosphonium bromide

: 143207-64-1
6-tert-butyldimethylsilyloxy-2-hydroxybenzaldehyde

: 143207-65-2
(E)-6-tert-butyldimethylsilyloxy-2-hydroxystilbene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 8h;
DOI:10.1248/cpb.40.1130

Reference yield:

: 143207-64-1
6-tert-butyldimethylsilyloxy-2-hydroxybenzaldehyde

: 143207-66-3
(E)-2,6-dihydroxystilbene

Guidance literature:: Multi-step reaction with 2 steps

1: 13 percent / tert-BuOK / tetrahydrofuran / 8 h

2: 100 percent / tetra-n-butylammonium fluoride (TBAF) / tetrahydrofuran / 0.17 h / 0 °C

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1248/cpb.40.1130