Phenol, 4-(6-amino-9H-purin-9-yl)-

Base Information

Chemical Name:Phenol, 4-(6-amino-9H-purin-9-yl)-
CAS No.:143308-63-8
Molecular Formula:C11H9N5O
Molecular Weight:227.225
Hs Code.:
DSSTox Substance ID:DTXSID30435341
Wikidata:Q82250192

Synonyms:Phenol, 4-(6-amino-9H-purin-9-yl)-;143308-63-8;DTXSID30435341

Suppliers and Price of Phenol, 4-(6-amino-9H-purin-9-yl)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenol, 4-(6-amino-9H-purin-9-yl)-

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:227.08070993
Heavy Atom Count:17
Complexity:269

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1N2C=NC3=C(N=CN=C32)N)O

Technology Process of Phenol, 4-(6-amino-9H-purin-9-yl)-

There total 8 articles about Phenol, 4-(6-amino-9H-purin-9-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 106-41-2
4-bromo-phenol

: 66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9
adenine

: 143308-63-8
4-(6-aminopurin-9-yl)phenol

Guidance literature:: With N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; sodium L-ascorbate; potassium hydroxide; copper(I) bromide; In water; N,N-dimethyl-formamide; at 120 ℃; for 48h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/c3cc48642g

Reference yield:

: 17793-95-2
cis-1,2-dihydrocatechol

: 143308-63-8
4-(6-aminopurin-9-yl)phenol

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / p-TsOH / CH₂Cl₂ / 1 h / -15 - -10 °C

2: 81 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 8 h / 0 °C

3: 90 percent / <(i-PrO)3P>4Pd / tetrahydrofuran; dimethylsulfoxide; hexane / 1) 0 deg C, 3 h, 2) rt, 16 h

4: 64 percent / methanol; dimethylsulfoxide / 16 h / 90 °C

5: 90 percent / dimethylaminopyridine, Et₂NSF₃ / CH₂Cl₂ / 1) -78 deg C to rt, 2 h, 2) rt, 22 h

6: 30percent aq. NH₄OH / methanol / 12 h

7: 10 percent aq. HCl / 3 h

With hydrogenchloride; dmap; ammonium hydroxide; diethylamino-sulfur trifluoride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; C₃₆H₈₄O₁₂P₄Pd; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00048a018

Reference yield:

: 80409-75-2,343865-40-7
cis-2,2-dimethyl-3a,7a-dihydrobenzo[1,3]dioxole

: 143308-63-8
4-(6-aminopurin-9-yl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: 81 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 8 h / 0 °C

2: 90 percent / <(i-PrO)3P>4Pd / tetrahydrofuran; dimethylsulfoxide; hexane / 1) 0 deg C, 3 h, 2) rt, 16 h

3: 64 percent / methanol; dimethylsulfoxide / 16 h / 90 °C

4: 90 percent / dimethylaminopyridine, Et₂NSF₃ / CH₂Cl₂ / 1) -78 deg C to rt, 2 h, 2) rt, 22 h

5: 30percent aq. NH₄OH / methanol / 12 h

6: 10 percent aq. HCl / 3 h

With hydrogenchloride; dmap; ammonium hydroxide; diethylamino-sulfur trifluoride; 3-chloro-benzenecarboperoxoic acid; C₃₆H₈₄O₁₂P₄Pd; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00048a018