3-hydrazinyl-phenylmethanol

Base Information

• Chemical Name: 3-hydrazinyl-phenylmethanol
• CAS No.: 143445-58-3
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Mol file: 143445-58-3.mol

Synonyms:3-hydrazinobenzyl alcohol;3-hydrazinobenzylalcohol;amino-5- (hydroxymethyl) aniline;m-hydroxymethylphenylhydrazine;

Chemical Property of 3-hydrazinyl-phenylmethanol

Chemical Property:

• Melting Point: 268 °C
• Boiling Point: 334.8±25.0 °C(Predicted)
• PKA: 14.45±0.10(Predicted)
• PSA: 58.28000
• Density: 1.257±0.06 g/cm3(Predicted)
• LogP: 1.23780

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydrazinyl-phenylmethanol

There total 2 articles about 3-hydrazinyl-phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

3-aminobenzenemethanol (1877-77-6) → m-(hydroxymethyl)phenylhydrazine (143445-58-3)

Guidance literature:

3-aminobenzenemethanol; With hydrogenchloride; sodium nitrite; In water; at 0 ℃; for 0.5h;

With tin(II) chloride dihdyrate; In water; at 0 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2015.10.019

Reference yield:

→ m-(hydroxymethyl)phenylhydrazine (143445-58-3)

Guidance literature:

Reference yield: 30.0%

ethyl 4-acetyl-1-ethyl-1,6-dihydro-5-nitro-6-oxopyridazine-3-carboxylate (1228805-34-2) + m-(hydroxymethyl)phenylhydrazine (143445-58-3) → ethyl 6-ethyl-6,7-dihydro-2-(3-(hydroxymethyl)phenyl)-3-methyl-7-oxo-2H-pyrazolo[3,4-d]pyridazine-4-carboxylate (1228804-59-8)

Guidance literature:

In ethanol; Heating;

DOI:10.1016/j.bmc.2010.03.066

upstream raw materials:

3-aminobenzenemethanol

Downstream raw materials:

(1,3,3-Trimethyl-2-methylene-2,3-dihydro-1H-indol-6-yl)-methanol

ethyl 6-ethyl-6,7-dihydro-2-(3-(hydroxymethyl)phenyl)-3-methyl-7-oxo-2H-pyrazolo[3,4-d]pyridazine-4-carboxylate