L-PriMapterin

Base Information

• Chemical Name: L-PriMapterin
• CAS No.: 2636-52-4
• Molecular Formula: C₉H₁₁N₅O₃
• Molecular Weight: 237.218
• Mol file: 2636-52-4.mol

Synonyms:1,2-Propanediol,1-(2-amino-4-hydroxy-7-pteridinyl)-, L-erythro- (8CI); 4(1H)-Pteridinone,2-amino-7-(1,2-dihydroxypropyl)-, [S-(R*,S*)]-; 4(1H)-Pteridinone,2-amino-7-[(1R,2S)-1,2-dihydroxypropyl]- (9CI); 7-Biopterin; L-Primapterin;Primapterin

Chemical Property of L-PriMapterin

Chemical Property:

• Vapor Pressure: 1.4E-13mmHg at 25°C
• Melting Point: >255°C (dec.)
• Boiling Point: 564.5°Cat760mmHg
• PKA: 14.62±0.20(Predicted)
• Flash Point: 295.2°C
• PSA: 139.00000
• Density: 1.86g/cm³
• LogP: -0.94810
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Aqueous Acid (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

L-Primapterin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 7-Biopterin is a 7-substituted pterin. It is formed by non-enzymatic rearrangement of 4a-hydroxy-tetrahydropterin in the absence of pterin-4a-carbinolamine dehydratase (PCD) in vitro and levels are elevated in the urine of hyperphenylalaninemia patients carrying heterozygous mutations in the PCBD gene encoding PCD.
• Uses: 7-Substituted pterins, a new class of mammalian pteridines. Primapterin, Anapterin, and 6-Oxo-primapterin, three new 7-substituted pterins identified in a patient with hyperphenylalaninemia.

Technology Process of L-PriMapterin

There total 2 articles about L-PriMapterin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

2,5,6-triamino-3,4-dihydro-4-pyrimidinone (1004-75-7) + C6H13N3O4 → L-Primapterin (2636-52-4)

Guidance literature:

With sodium acetate; In 1,4-dioxane; water; 1.) 0.5 h, r.t., 2.) 3 h, 60 - 70 deg C;

DOI:10.1002/hlca.19900730213

Reference yield:

5-deoxy-L-arabinose (13039-56-0) → L-Primapterin (2636-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4m CH₃COONa / dioxane; H₂O / 1 h / 22 °C

2: 8 percent / 4M CH₃COONa / dioxane; H₂O / 1.) 0.5 h, r.t., 2.) 3 h, 60 - 70 deg C

With sodium acetate; In 1,4-dioxane; water;

DOI:10.1002/hlca.19900730213

upstream raw materials:

2,5,6-triamino-3,4-dihydro-4-pyrimidinone

5-deoxy-L-arabinose

Refernces