Indalpine

Base Information

• Chemical Name: Indalpine
• CAS No.: 63758-79-2
• Molecular Formula: C15H20N2
• Molecular Weight: 228.337
• Hs Code.: 2933990090
• European Community (EC) Number: 264-445-4
• UNII: V35562QSVT
• DSSTox Substance ID: DTXSID80213196
• Nikkaji Number: J19.462J
• Wikipedia: Indalpine
• Wikidata: Q6015666
• NCI Thesaurus Code: C170063
• Pharos Ligand ID: SLH388X93X17
• Metabolomics Workbench ID: 152030
• ChEMBL ID: CHEMBL276520
• Mol file: 63758-79-2.mol

Synonyms:(3-indolyl-2-ethyl)piperidine;4-(2-(3-indolyl)ethyl)piperidine;indalpine;indalpine monohydrochloride;LM 5008;LM 50084;Upstene

Chemical Property of Indalpine

Chemical Property:

• Vapor Pressure: 9.01E-07mmHg at 25°C
• Refractive Index: 1.595
• Boiling Point: 405.1 °C at 760 mmHg
• Flash Point: 198.8 °C
• PSA: 27.82000
• Density: 1.07 g/cm³
• LogP: 3.42890
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 228.162648646
• Heavy Atom Count: 17
• Complexity: 235

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

INDALPINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1CCC2=CNC3=CC=CC=C32
• Description: Indalpine is a non-tricyclic antidepressant with a serotonin selective profile. It is 6-7 times more potent than fluoxetine and clomipramine in inhibiting serotonin reuptake in vitro in rat brain synaptosomes. Statistically significant clinical effects within one week of onset of treatment have been reported. An anxiolytic effect may accompany the antidepressant effect. Indalpine appears devoid of anticholinergic and cardiovascular side effects and does not promote weight gain or affect appetite.
• Therapeutic Function: Antidepressant

Technology Process of Indalpine

There total 5 articles about Indalpine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-(2-pyridin-4-yl-ethyl)-indole (16571-49-6) → indalpine (63758-79-2)

Guidance literature:

With hydrogen; Adam’s catalyst; In acetic acid; Ambient temperature;

DOI:10.1021/jm00186a005

Reference yield:

4-vinylpyridine (100-43-6,329041-72-7) → indalpine (63758-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / acetic acid / 5 h / Heating

2: 74 percent / H₂ / Pt₂O / acetic acid / Ambient temperature

With hydrogen; Adam’s catalyst; In acetic acid;

DOI:10.1021/jm00186a005

Reference yield:

indole (120-72-9) → indalpine (63758-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / acetic acid / 5 h / Heating

2: 74 percent / H₂ / Pt₂O / acetic acid / Ambient temperature

With hydrogen; Adam’s catalyst; In acetic acid;

DOI:10.1021/jm00186a005

upstream raw materials:

3-(2-pyridin-4-yl-ethyl)-indole

4-vinylpyridine

indole

Refernces

• 1、 Gueremy, Claude,Audiau, Francois,Champseix, Alain,Uzan, Andre,Fur, Gerard Le,Rataud, Jean. "3-(4-Piperidinylalkyl)indoles, Selective Inhibitors of Neuronal 5-Hydroxytryptamine Uptake". . p. 1306 - 1310. Retrieved 2007/10/02.