3-(4-Piperidinylalkyl)indoles, Selective Inhibitors of Neuronal 5-Hydroxytryptamine Uptake

DOI: 10.1021/jm00186a005

Source and publish data:

Journal of Medicinal Chemistry p. 1306 - 1310 (1980)

Update date:2022-08-06

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Authors:

Gueremy, Claude

Audiau, Francois

Champseix, Alain

Uzan, Andre

Fur, Gerard Le

Rataud, Jean

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Article abstract of DOI:10.1021/jm00186a005

A series 3-(4-piperidinylalkyl)indoles was synthesized and tested as uptake inhibitors of biogenic amines.Some of these compounds are potent and very selective in blocking the 5-hydroxytryptamine (5-HT) uptake, as evidenced by biochemical data and behavioral tests.A discussion on structure-activity relationships is given.The most interesting member of the series, indalpine, 3-<2-(4-piperidinyl)ethyl>indole (1), was selected for clinical studies.

Full text of DOI:10.1021/jm00186a005

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