Journal of Medicinal Chemistry p. 1306 - 1310 (1980)
Update date:2022-08-06
Topics:
Gueremy, Claude
Audiau, Francois
Champseix, Alain
Uzan, Andre
Fur, Gerard Le
Rataud, Jean
A series 3-(4-piperidinylalkyl)indoles was synthesized and tested as uptake inhibitors of biogenic amines.Some of these compounds are potent and very selective in blocking the 5-hydroxytryptamine (5-HT) uptake, as evidenced by biochemical data and behavioral tests.A discussion on structure-activity relationships is given.The most interesting member of the series, indalpine, 3-<2-(4-piperidinyl)ethyl>indole (1), was selected for clinical studies.
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