(2-Bromophenyl)dichlorophosphane

Base Information

• Chemical Name: (2-Bromophenyl)dichlorophosphane
• CAS No.: 5274-51-1
• Molecular Formula: C23H25NO3
• Molecular Weight: 257.882
• European Community (EC) Number: 858-797-3
• Mol file: 5274-51-1.mol

Synonyms:(2-Bromophenyl)dichlorophosphane;5274-51-1;(2-bromophenyl)-dichlorophosphane;MFCD31719805;EN300-6503877

Chemical Property of (2-Bromophenyl)dichlorophosphane

Chemical Property:

• Vapor Pressure: 5.96E-11mmHg at 25°C
• Boiling Point: 520.9°Cat760mmHg
• Flash Point: 268.8°C
• Density: 1.21g/cm³
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 0
• Exact Mass: 255.86111
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)P(Cl)Cl)Br

Technology Process of (2-Bromophenyl)dichlorophosphane

There total 4 articles about (2-Bromophenyl)dichlorophosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N,N',N'-tetraethyl(2-bromophenyl)phosphonous acid diamide → ortho-dichlorophosphinobromobenzene (5274-51-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 1h;

DOI:10.1002/chem.201404846

Reference yield: 55.0%

2-bromobenzenediazonium tetrafluoroborate (10448-07-4) → ortho-dichlorophosphinobromobenzene (5274-51-1)

Guidance literature:

With aluminium; phosphorus trichloride; In acetonitrile; Inert atmosphere;

DOI:10.1021/om2004095

Reference yield:

2,3-dibromobenzene (583-53-9) → ortho-dichlorophosphinobromobenzene (5274-51-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 2 h / -110 °C

1.2: -110 - 20 °C

2.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane;

DOI:10.1002/chem.201404846

upstream raw materials:

2-bromobenzenediazonium tetrafluoroborate

2,3-dibromobenzene

Downstream raw materials:

ortho-bis(dimethylamino)phosphinobromobenzene

(2-bromophenyl)diphenylphosphane

(o-bromophenyl)dimethylphosphine

1-(diethylphosphino)-2-bromobenzene