1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-

Base Information

Chemical Name:1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-
CAS No.:143572-86-5
Molecular Formula:C19H18O5
Molecular Weight:326.349
Hs Code.:
DSSTox Substance ID:DTXSID70458514
Wikidata:Q82281860
Mol file:143572-86-5.mol

Synonyms:143572-86-5;1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-;SCHEMBL8051267;DTXSID70458514

Suppliers and Price of 1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:326.11542367
Heavy Atom Count:24
Complexity:455

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC(=C2C(=C1)C=C(OC2=O)COCC3=CC=CC=C3)OC

Technology Process of 1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]-

There total 6 articles about 1H-2-Benzopyran-1-one, 6,8-dimethoxy-3-[(phenylmethoxy)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268603-53-7
methyl 2-(3-(benzyloxy)-2-oxopropyl)-4,6-dimethoxybenzoate

: 143572-86-5
3-((benzyloxy)methyl)-6,8-dimethoxy-1H-isochromen-1-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol103117j

Reference yield: 67.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 846003-80-3
6,8-dimethoxy-3-hydroxymethylisocoumarin

: 143572-86-5
3-((benzyloxy)methyl)-6,8-dimethoxy-1H-isochromen-1-one

Guidance literature:: With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; at 20 ℃;
DOI:10.1021/ol202923u

Reference yield:

: 104863-68-5
2-(benzyloxy)-N-methoxy-N-methylacetamide

: 143572-86-5
3-((benzyloxy)methyl)-6,8-dimethoxy-1H-isochromen-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 20 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol103117j