2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

Base Information

Chemical Name:2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid
CAS No.:1268603-55-9
Molecular Formula:C₂₉H₂₈O₈
Molecular Weight:504.537
Hs Code.:

Synonyms:2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

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Chemical Property of 2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

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Technology Process of 2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

There total 3 articles about 2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6110-37-8
methyl 2,4-dimethoxy-6-methylbenzoate

: 143572-86-5
3-((benzyloxy)methyl)-6,8-dimethoxy-1H-isochromen-1-one

: 1268603-55-9
2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

Guidance literature:: methyl 2,4-dimethoxy-6-methylbenzoate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

3-((benzyloxy)methyl)-6,8-dimethoxy-1H-isochromen-1-one; In tetrahydrofuran; hexane; at -78 ℃; for 20h; Further stages; Inert atmosphere;
DOI:10.1021/ol103117j

Reference yield:

: 1268603-53-7
methyl 2-(3-(benzyloxy)-2-oxopropyl)-4,6-dimethoxybenzoate

: 1268603-55-9
2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 20 h / -78 °C / Inert atmosphere

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol103117j

Reference yield:

: 6110-37-8
methyl 2,4-dimethoxy-6-methylbenzoate

: 1268603-55-9
2-(3-((benzyloxy)methyl)-1-hydroxy-6,8-dimethoxynaphthalen-2-yl)-4,6-dimethoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 20 h / -78 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: 20 h / -78 °C / Inert atmosphere

With n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol103117j