Technology Process of Cyclohexanepropanoyl chloride, a-2-propenyl-, (S)-
There total 6 articles about Cyclohexanepropanoyl chloride, a-2-propenyl-, (S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl chloride / 2 h / Heating
2: N-methylmorpholine / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, overnight
3: 1.) LDA, 2.) tetrabutylammonium iodide / 1.) THF, 0 deg C, 2 h, 2.) THF, reflux, overnight
4: 83 percent / H2O, HCl / dioxane / Heating
5: oxalyl chloride / 1.5 h / Heating
With
4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/ja00046a010
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / Jones reagent / acetone / Ambient temperature
2: oxalyl chloride / 2 h / Heating
3: N-methylmorpholine / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, overnight
4: 1.) LDA, 2.) tetrabutylammonium iodide / 1.) THF, 0 deg C, 2 h, 2.) THF, reflux, overnight
5: 83 percent / H2O, HCl / dioxane / Heating
6: oxalyl chloride / 1.5 h / Heating
With
4-methyl-morpholine; hydrogenchloride; jones reagent; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; lithium diisopropyl amide;
In
tetrahydrofuran; 1,4-dioxane; acetone;
DOI:10.1021/ja00046a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA, 2.) tetrabutylammonium iodide / 1.) THF, 0 deg C, 2 h, 2.) THF, reflux, overnight
2: 83 percent / H2O, HCl / dioxane / Heating
3: oxalyl chloride / 1.5 h / Heating
With
hydrogenchloride; oxalyl dichloride; water; tetra-(n-butyl)ammonium iodide; lithium diisopropyl amide;
In
1,4-dioxane;
DOI:10.1021/ja00046a010
