Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-

Base Information

Chemical Name:Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-
CAS No.:143782-28-9
Molecular Formula:C13H10F3N3OS
Molecular Weight:313.303
Hs Code.:

Synonyms:

Suppliers and Price of Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-

Chemical Property:

PSA：88.22000
LogP:2.97058

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-(4,4-Dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-trifluoromethylbenzonitrile is used in the preparation of MDV 3100 (Enzalutamide)(M199800) which is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.

Technology Process of Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)-

There total 4 articles about Benzonitrile, 4-(4,4-dimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 22421-97-2
methyl 2-chloroisobutyrate

: 1-[4-cyano-3-(trifluoromethyl)phenyl]thiourea

: 143782-28-9
2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile

Guidance literature:: With triethylamine; at 80 - 90 ℃; for 5h;

Reference yield: 65.1%

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 15998-93-3
5,5-dimethylimidazolidine-2-thione-4-one

: 143782-28-9
2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile

Guidance literature:: 5,5-dimethylimidazolidine-2-thione-4-one; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.5h;

4-bromo-2-(trifluoromethyl)benzonitrile; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 143782-28-9
2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: benzoyl chloride / acetone / 1 h / 40 - 45 °C

2: triethylamine / 5 h / 80 - 90 °C

With benzoyl chloride; triethylamine; In acetone;