22421-97-2

Basic information

• Product Name: methyl 2-chloro-2-methylpropanoate
• Synonyms: methyl 2-chloro-2-methylpropanoate;Propanoic acid,2-chloro-2-methyl-, methyl ester
• CAS NO: 22421-97-2
• Molecular Formula: C₅H₉ClO₂
• Molecular Weight: 136.5768
• Mol File: 22421-97-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 131.9°C at 760 mmHg
• Flash Point: 27°C
• Density: 1.084g/cm³
• Vapor Pressure: 9.09mmHg at 25°C
• Refractive Index: 1.418
• CAS DataBase Reference: methyl 2-chloro-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloro-2-methylpropanoate(22421-97-2)
• EPA Substance Registry System: methyl 2-chloro-2-methylpropanoate(22421-97-2)

Safety Data

• Hazardous Substances Data: 22421-97-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

The Journal of Organic Chemistry, 43, p. 3687, 1978 DOI: 10.1021/jo00413a010

Upstream product

• 67-56-1 methanol 
• 1606-30-0 1-Nitro-2-methyl-1-propen 
• 3331-60-0 chloroisobutyronitrile 
• 594-58-1 2-chloro-2-methylpropanoic acid 
• 20599-48-8 2-chloro-2-methyl-1-nitro-propane 
• 2589-57-3 dimethyl 2,2'-azobis(isobutyrate) 
• 5014-47-1 N-chloro-N-phenylbenzamide 
• 71-43-2 benzene 
• 579-11-3 N-chloroacetanilide 
• 36998-38-6 2-(methylpropylidene)-1,3-dithiane 
• 917-93-1 2-chloroisobutyraldehyde 
• 68963-60-0 2-chloroisobutyraldehyde dimethyl acetal 
• 67-66-3 chloroform 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 

Downstream Products

• 80-62-6 methacrylic acid methyl ester 
• 7462-75-1 dimethylcarbamylmethyl chloride 
• 3852-11-7 3-methoxy-2-methylpropionic acid methyl ester 
• 143782-28-9 2-(trifluoromethyl)-4-(4,4-dimethyl 5-oxo-2-thioimidazolin-1-yl)benzonitrile 
• 915087-33-1 enzalutamide 
• 15998-93-3 5,5-dimethylimidazolidine-2-thione-4-one 
• 72278-52-5 methyl 2-methyl-2-phenoxypropionate 
• 81466-36-6 2-(4-hydroxyphenoxy)-2-methylpropionic acid methyl ester 

Relevant articles and documents

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METHOD FOR PRODUCING UNSATURATED ACID AND/OR UNSATURATED ACID ESTER

The present invention relates to a method for producing an unsaturated acid and/or an unsaturated acid ester, containing a process A of reacting a compound (1) represented by the following formula (1) at a temperature of 0° C. to 350° C. in the presence of a Br?nsted acid catalyst and/or a Lewis acid catalyst, to prepare a compound (2) represented by the following formula (2); in which each of R1, R2 and R4 independently represents a hydrogen atom, a deuterium atom or an alkyl group; each of R3 and R5 independently represents a hydrogen atom or a deuterium atom; R6 represents a hydrogen atom, a deuterium atom, or an alkyl group or an aryl group; and X represents a chlorine atom, a fluorine atom, a bromine atom, or an iodine atom.

Electrophilicities of α-chlorinating agents used in organocatalysis

Kinetics of the reactions of the chlorinating agents 1a-c with π-nucleophiles have been studied to include these compounds in our comprehensive electrophilicity scale.