5-benzyloxybenzylbarbituric acid

Base Information

• Chemical Name: 5-benzyloxybenzylbarbituric acid
• CAS No.: 138660-08-9
• Molecular Formula: C18H16 N2 O4
• Molecular Weight: 0
• Mol file: 138660-08-9.mol

Synonyms:5-(m-Benzyloxybenzyl)barbituricacid; NSC 685357

Chemical Property of 5-benzyloxybenzylbarbituric acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 91.48000
• Density: 1.292g/cm³
• LogP: 2.34210

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-benzyloxybenzylbarbituric acid

There total 2 articles about 5-benzyloxybenzylbarbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-(3-(benzyloxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione (154021-69-9) → 5-(m-benzyloxy)benzylbarbituric acid (138660-08-9)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2010.08.026

Reference yield:

3-Benzyloxybenzaldehyde (1700-37-4) → 5-(m-benzyloxy)benzylbarbituric acid (138660-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂O / 1 h / Heating

2: 82 percent / sodium borohydride / ethanol / 2 h

With sodium tetrahydroborate; In ethanol; water;

Reference yield:

5-(m-benzyloxy)benzylbarbituric acid (138660-08-9) → 1-<(2-hydroxyethoxy)methyl>-5-(m-benzyloxy)benzylbarbituric acid

Guidance literature:

Multi-step reaction with 3 steps

1: hexamethyldisilazane / Heating

2: 50 percent / aluminum chloride / 1,2-dichloro-ethane / 48 h / Ambient temperature

3: 82 percent / NaOMe / methanol / 2 h / Ambient temperature

With aluminium trichloride; sodium methylate; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; 1,2-dichloro-ethane;

upstream raw materials:

5-(3-(benzyloxy)benzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

3-Benzyloxybenzaldehyde

Downstream raw materials:

5-(3-Benzyloxy-benzyl)-2,4,6-tris-trimethylsilanyloxy-pyrimidine

1-<(2-acetoxyethoxy)methyl>-5-(m-benzyloxy)benzylbarbituric acid

Refernces

• 1、 Tzeng, Cherng-Chyi,Panzica, Raymond P.,Naguib, Fardos N.M.,Kouni, Mahmoud H. el. "Synthesis of a New Class of Uridine Phoshorylase Inhibitors". . p. 1399 - 1404. Retrieved 2007/10/02.