154021-69-9Relevant academic research and scientific papers
Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase
Cui, Huaqing,Ruda, Gian Filippo,Carrero-Lérida, Juana,Ruiz-Pérez, Luis M.,Gilbert, Ian H.,González-Pacanowska, Dolores
, p. 5140 - 5149 (2010)
Plasmodium falciparum purine nucleoside phosphorylase (PfPNP) has a central role in purine salvage and inhibitors of the enzyme have been shown to have antiplasmodial activity. The enzyme preferentially uses inosine as substrate (Km = 5 μM, ks
New compounds having skin whitening, antioxidant and PPAR activity, and medical use thereof
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Paragraph 0449-0450; 0476, (2017/04/14)
PURPOSE: A novel compound with skin whitening, antioxidation, and PPAR activation effects, and a medical use thereof are provided to be used for a pharmaceutical composition or a cosmetic product. CONSTITUTION: A compound is denoted by chemical formula 1. A skin whitening composition contains the compound as an active ingredient. An antioxidative composition for preventing or treating oxidative diseases contains the compound of chemical formula 1 as an active ingredient. The oxidative diseases are selected among skin aging, pigmentation, wrinkling, psoriasis, or eczema. The composition prevents or treats diseases which are regulated by PPAR(peroxisome proliferator-activated receptor) activity. The PPAR includes PPAR alpha or PPAR gamma.
Synthesis of a New Class of Uridine Phoshorylase Inhibitors
Tzeng, Cherng-Chyi,Panzica, Raymond P.,Naguib, Fardos N.M.,Kouni, Mahmoud H. el
, p. 1399 - 1404 (2007/10/02)
A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid.Among them 1--5-(m-benzyloxy)benzylbarbituric acid (37, BBBA) is the most promising having a Ki value of 1.1 +/- 0.2 nM wit
