N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide

Base Information

Chemical Name:N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide
CAS No.:86523-83-3
Molecular Formula:C20H26N4O2
Molecular Weight:354.446
Hs Code.:
DSSTox Substance ID:DTXSID601006889
ChEMBL ID:CHEMBL294462
Mol file:86523-83-3.mol

Synonyms:BRN 5630223;86523-83-3;1-Piperazinepropanamide, N-(4-(1-hydroxyethyl)phenyl)-4-(2-pyridinyl)-;N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide;CHEMBL294462;SCHEMBL11007508;DTXSID601006889;LS-113194;N-[4-(1-HYDROXYETHYL)PHENYL]-3-[4-(PYRIDIN-2-YL)PIPERAZIN-1-YL]PROPANAMIDE

Suppliers and Price of N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1-PIPERAZINEPROPANAMIDE, N-(4-(1-HYDROXYETHYL)PHENYL)-4-(2-PYRIDINYL)- 95.00%
5MG
$ 505.38

Total 3 raw suppliers

Chemical Property of N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide

Chemical Property:

Vapor Pressure:9.98E-16mmHg at 25°C
Boiling Point:609.9°Cat760mmHg
Flash Point:322.6°C
PSA：68.70000
Density:1.213g/cm³
LogP:2.36160
XLogP3:1.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:354.20557608
Heavy Atom Count:26
Complexity:432

Purity/Quality:: 1-PIPERAZINEPROPANAMIDE, N-(4-(1-HYDROXYETHYL)PHENYL)-4-(2-PYRIDINYL)- 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)NC(=O)CCN2CCN(CC2)C3=CC=CC=N3)O

Technology Process of N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide

There total 4 articles about N-(4-(1-Hydroxyethyl)phenyl)-4-(2-pyridinyl)-1-piperazinepropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 86523-82-2
N-(4-acetylphenyl)-3-<4-(2-pyridinyl)-1-piperazinyl>propanamide

: 86523-83-3
N-<4-(1-hydroxyethyl)phenyl>-3-<4-(2-pyridinyl)-1-piperazinyl>propanamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; for 8h;
DOI:10.1021/jm00384a002

Reference yield:

: 34803-66-2
1-(2-pyridyl)piperazine

: 86523-83-3
N-<4-(1-hydroxyethyl)phenyl>-3-<4-(2-pyridinyl)-1-piperazinyl>propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / toluene / Heating

2: 49 percent / NaBH₄ / ethanol / 8 h

With sodium tetrahydroborate; In ethanol; toluene;
DOI:10.1021/jm00384a002

Reference yield:

: 99-92-3
p-aminobenzophenone

: 86523-83-3
N-<4-(1-hydroxyethyl)phenyl>-3-<4-(2-pyridinyl)-1-piperazinyl>propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / aq. NaOAc / acetic acid / 1 h / Ambient temperature

2: 55 percent / toluene / Heating

3: 49 percent / NaBH₄ / ethanol / 8 h

With sodium tetrahydroborate; sodium acetate; In ethanol; acetic acid; toluene;
DOI:10.1021/jm00384a002