Technology Process of 1,3,2-Dioxaborolane,
2-[chloro(3-methoxyphenyl)methyl]-4,4,5,5-tetramethyl-
There total 2 articles about 1,3,2-Dioxaborolane,
2-[chloro(3-methoxyphenyl)methyl]-4,4,5,5-tetramethyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
dropwise addn. of an equimolar amt. of the Grignard reagent in THF to a soln. of the boronate in THF at -75°C with stirring; the mixture was allowed to reach room temp. for 1 h and was kept at 20-25°C overnight; performed under Ar;; concn. under vac.; the residue was dissolved in ether; filtration; evapn.;;
DOI:10.1016/0022-328X(92)83330-K
- Guidance literature:
-
In
tetrahydrofuran;
dropwise addn. of an equimolar amt. of the Grignard reagent in THF to a soln. of the boronate in THF at -75°C with stirring; the mixture was allowed to reach room temp. for 1 h and was kept at 20-25°C overnight; performed under Ar;; concn. under vac.; the residue was dissolved in ether; filtration; evapn.;;
DOI:10.1016/0022-328X(92)83330-K
- Guidance literature:
-
With
water; phenyllithium;
In
tetrahydrofuran; diethyl ether; cyclohexane;
Ar atm.; addn. of PhLi in cyclohexane/ether to α-picoline in THF; stirring at room temp. for 1 h; dropwise addn. to a soln. of the B-compd. in THF at -70°C with stirring; kept at 20-25°C for 20 h; stirring with Na-bicarbonate for 2h;; filtration; concn. of the filtrate under vac.; the residue was dissolved in CHCl3; filtration; evapn.; crystn. from hexane; elem. anal.;;
DOI:10.1016/0022-328X(92)83330-K
