N-(2-chloro-4-iodophenyl)methanesulfonamide

Base Information

• Chemical Name: N-(2-chloro-4-iodophenyl)methanesulfonamide
• CAS No.: 143937-72-8
• Molecular Formula: C7H7ClINO2S
• Molecular Weight: 331.562
• DSSTox Substance ID: DTXSID901260034

Synonyms:N-(2-chloro-4-iodophenyl)methanesulfonamide;143937-72-8;SCHEMBL4641881;FIVGCTGRVVNMIN-UHFFFAOYSA-N;DTXSID901260034

Chemical Property of N-(2-chloro-4-iodophenyl)methanesulfonamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 330.89307
• Heavy Atom Count: 13
• Complexity: 264

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)I)Cl

Technology Process of N-(2-chloro-4-iodophenyl)methanesulfonamide

There total 1 articles about N-(2-chloro-4-iodophenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-chloro-4-iodoaniline (42016-93-3) + methanesulfonyl chloride (124-63-0) → N-(2-chloro-4-iodophenyl)methanesulfonamide (143937-72-8)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm0502790

Reference yield: 100.0%

N-(2-chloro-4-iodophenyl)methanesulfonamide (143937-72-8) + dicyanozinc (557-21-1) → N-(4-cyano-2-chlorophenyl)methanesulfonamide (865878-58-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

DOI:10.1021/jm0502790

Reference yield: 81.0%

N-(2-chloro-4-iodophenyl)methanesulfonamide (143937-72-8) + copper(l) cyanide → N-(4-cyano-2-chlorophenyl)methanesulfonamide (865878-58-6)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 8h;

DOI:10.1016/j.bmc.2009.10.043

upstream raw materials:

2-chloro-4-iodoaniline

methanesulfonyl chloride

Downstream raw materials:

N-(4-cyano-2-chlorophenyl)methanesulfonamide

N-(4-iodophenyl)-methanesulfonamide

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