6-(2,5-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

Base Information

• Chemical Name: 6-(2,5-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE
• CAS No.: 143951-31-9
• Molecular Formula: C15H14N2O3S
• Molecular Weight: 302.354
• Mol file: 143951-31-9.mol

Synonyms:6-(2,5-Dimethoxy-phenyl)-2-methyl-imidazo[2,1-b]thiazole-5-carbaldehyde;

Chemical Property of 6-(2,5-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

Chemical Property:

• PSA: 81.07000
• LogP: 3.20090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(2,5-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE

There total 1 articles about 6-(2,5-DIMETHOXYPHENYL)-2-METHYLIMIDAZO[2,1-B]THIAZOLE-5-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(2,5-Dimethoxy-phenyl)-2-methyl-imidazo[2,1-b]thiazole (100849-93-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-methyl-6-(2,5-dimethoxyphenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde (143951-31-9)

Guidance literature:

With pyridine; trichlorophosphate; In chloroform; Heating;

DOI:10.1016/0223-5234(92)90159-X

Reference yield: 17.0%

ethyl acetoacetate (141-97-9) + 2-methyl-6-(2,5-dimethoxyphenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde (143951-31-9) → diethyl 4-[6-(2,5-dimethoxyphenyl)-2-methylimidazo[2,1-b][1,3]thiazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:

With ammonium hydroxide; In isopropyl alcohol; for 12h; Reflux;

DOI:10.1016/j.ejmech.2019.02.075

Reference yield: 11.0%

acetoacetic acid methyl ester (105-45-3) + 2-methyl-6-(2,5-dimethoxyphenyl)imidazo[2,1-b]thiazole-5-carboxaldehyde (143951-31-9) → C25H27N3O6S (1015756-61-2)

Guidance literature:

With ammonium hydroxide; In isopropyl alcohol; Heating;

DOI:10.1021/jm070681+

upstream raw materials:

6-(2,5-Dimethoxy-phenyl)-2-methyl-imidazo[2,1-b]thiazole

N,N-dimethyl-formamide

Downstream raw materials:

C₂₅H₂₇N₃O₆S

C₂₃H₁₉N₃O₄S

C₂₃H₁₈ClN₃O₃S

C₂₄H₂₁N₃O₄S

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