L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester
CAS No.:144156-18-3
Molecular Formula:C₂₅H₃₆N₂O₈
Molecular Weight:492.569
Hs Code.:
Mol file:144156-18-3.mol

L-Alanine,
N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen
ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

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Technology Process of L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester

There total 7 articles about L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-3-[[2-oxo-2-(2-propenyloxy)ethyl][(phen ylmethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98946-18-0
tert-Butyl 2,2,2-trichloroacetimidate

: 144156-14-9
N²-(tert-Butoxycarbonyl)-N³-(benzyloxycarbonyl)-N³-(carboxymethyl)-L-2,3-diaminopropanoic acid δ-allyl ester

: 144156-18-3
N²-(tert-Butoxycarbonyl)-N³-(benzyloxycarbonyl)-N³-(carboxymethyl)-L-2,3-diaminopropanoic acid α-tert-butyl δ-allyl ester

Guidance literature:: In dichloromethane; cyclohexane; for 30h; Ambient temperature;
DOI:10.1021/jo00050a013

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 144156-18-3
N²-(tert-Butoxycarbonyl)-N³-(benzyloxycarbonyl)-N³-(carboxymethyl)-L-2,3-diaminopropanoic acid α-tert-butyl δ-allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

2: 82 percent / Jones reagent / acetone / 1.5 h / Ambient temperature

3: 89 percent / CH₂Cl₂; cyclohexane / 30 h / Ambient temperature

With jones reagent; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; cyclohexane; water; acetone;
DOI:10.1021/jo00050a013

Reference yield:

: 124373-83-7
allyl 2-(tert-butoxycarbonylamino)acetate

: 144156-18-3
N²-(tert-Butoxycarbonyl)-N³-(benzyloxycarbonyl)-N³-(carboxymethyl)-L-2,3-diaminopropanoic acid α-tert-butyl δ-allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / HCl / dioxane / 0.5 h / Ambient temperature

2: 86 percent / NaBH₃CN / methanol / 1 h / Ambient temperature

3: 94 percent / NaHCO₃ / 16 h / Ambient temperature

4: 4N HCl / dioxane

5: NaHCO₃ / tetrahydrofuran; H₂O / 16 h / Ambient temperature

6: 82 percent / Jones reagent / acetone / 1.5 h / Ambient temperature

7: 89 percent / CH₂Cl₂; cyclohexane / 30 h / Ambient temperature

With hydrogenchloride; jones reagent; sodium cyanoborohydride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; cyclohexane; water; acetone;
DOI:10.1021/jo00050a013