98946-18-0

Basic information

• Product Name: tert-Butyl 2,2,2-trichloroacetimidate
• Synonyms: O-TERT BUTYL-2,2,2-TRICHLOROACETIMIDATE;N-(9-FLUORENYLMETHOXYCARBONYL)AMIDE;TERT-BUTYL 2,2,2-TRICHLOROACETIMIDATE;TBTA;T-BUTYL 2,2,2-TRICHLOROACETIMIDATE;TERT-BUTYL 2,2,2-TRICHLOROACETIMIDATE, 9 6%;T-BUTYL TRICHLOROACETIMIDATE;tert-Butyl 2,2,2-trichloroacetimidate 99%
• CAS NO: 98946-18-0
• Molecular Formula: C₆H₁₀Cl₃NO
• Molecular Weight: 218.51
• EINECS: -0
• Product Categories: Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry
• Mol File: 98946-18-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 21 °C(lit.)
• Boiling Point: 65 °C11 mm Hg(lit.)
• Flash Point: 131 °F
• Appearance: Clear colorless to pale yellow/Liquid or Low Melting Crystalline Mass
• Density: 1.222
• Vapor Pressure: 1.058mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• Storage Temp.: 2-8°C
• Solubility: Soluble in organic solvents, cyclo hexane.
• PKA: 2.49±0.70(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 1770049
• CAS DataBase Reference: tert-Butyl 2,2,2-trichloroacetimidate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 2,2,2-trichloroacetimidate(98946-18-0)
• EPA Substance Registry System: tert-Butyl 2,2,2-trichloroacetimidate(98946-18-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 10-22-36/37/38
• Safety Statements: 26-37/39-16-36/37-24/25
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• F: 10-21
• TSCA: No
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 98946-18-0(Hazardous Substances Data)

Usage

Uses

tert-Butyl 2,2,2-trichloroacetimidate is used to produce di-tert-butyl peroxide at temperature of -5°C. It may be used in the synthesis of N-α-Fmoc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine, caged building block. It may be used in the conversion of alcohols and carboxylic acids to their respective ethers and esters.

InChI:InChI=1/C6H10Cl3NO/c1-5(2,3)11-4(10)6(7,8)9/h10H,1-3H3

Upstream product

• 545-06-2 trichloroacetonitrile 
• 75-65-0 tert-butyl alcohol 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 33155-61-2 tert-butyl 2-(4-methoxyphenyl)acetate 
• 2109-72-0 4-tert-butoxy-1-nitrobenzene 
• 2901-11-3 ester tertiobutylique de l'acide phenyl-2 propionique 
• 122977-53-1 1-O-benzyl-3-O-tert-butylglycerol 
• 90367-83-2 tert-butyl α-phenethyl ether 
• 3354-66-3 tert-butyl 2-phenylethyl ether 
• 53913-96-5 tert-butyl 2-(bromomethyl)acrylate 
• 142448-82-6 N,N'-Di-tert-butyl-2,4,6-trimethyl-benzene-1,3-diamine 
• 132903-76-5 (S)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid tert-butyl ester 
• 135777-62-7 (4R)-1-benzyl-4-(t-butyloxycarbonyl)-3,3-difluoroazetidin-2-one 
• 122977-55-3 (S)-1-[Bis-(4-methoxy-phenyl)-methyl]-aziridine-2-carboxylic acid tert-butyl ester 
• 151436-20-3 tert-butyl (S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoate 
• 133464-42-3 N-(Benzyloxycarbonyl)-O-allyl-L-serine tert-butyl ester 
• 144156-18-3 N²-(tert-Butoxycarbonyl)-N³-(benzyloxycarbonyl)-N³-(carboxymethyl)-L-2,3-diaminopropanoic acid α-tert-butyl δ-allyl ester 

Relevant articles and documents

Benzo [d] [1, 3] oxathiol, benzo [d] [1, 3] benzo [d] [1, 3] oxathiol 3 - oxide or 3, 3 - dioxide compounds and G protein-coupled receptor 119 oxathiol action of number as method/use

There are provided compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide, and benzo[d][1,3]oxathiole 3,3-dioxide, as well as uses/methods related thereto, including treatment of diseases and condition associated with GPR119 dysregulation, Type 2 diabetes mellitus, and related metabolic disorders.

Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor

Abstract A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the BI-DIME ligands for a ligand-controlled Suzuki cross-coupling and an unprecedented bis(trifluoromethane)sulfonamide-catalyzed tert-butylation renders the synthesis of this complex molecule robust, safe, and economical. Furthermore, the overall synthesis was conducted in an asymmetric and diastereoselective fashion with respect to the imbedded atropisomer. Atropselective: An efficient asymmetric synthesis of an atropisomeric HIV inhibitor has been accomplished. The combination of a copper-catalyzed acylation with the implementation of BI-DIME ligands for a ligand-controlled Suzuki cross-coupling and an unprecedented bis(trifluoromethane)sulfonamide-catalyzed tert-butylation renders the synthesis of this complex molecule robust, safe, and economical.

Bifunctional Metal Chelating Conjugates

The present invention is directed to metal chelating conjugates for use as metallopharmaceutical diagnostics or therapeutic agents. Specifically, conjugates of the present invention include a carrier, a metal coordinating moiety, and a urea linkage chemically linking the metal coordinating moiety to the carrier. The carrier is generally utilized for targeting the conjugate to a biological tissue or organ.